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Tbio
IER2
Immediate early response gene 2 protein

Protein Summary
Description
DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292433
  • ENSP00000292433
  • ENSG00000160888
  • ENST00000587885
  • ENSP00000467294
  • ENST00000588173
  • ENSP00000465617

Symbol
  • ETR101
  • PIP92
  • ETR101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.99
transcription factor binding site profile
0.97
PubMedID
0.95
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.38   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.38   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999999996
p_ni:  4e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
ZBTB40
Tbio
Family:  TF
Novelty:  0.17413605
p_int:  0.999999994
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
KPNA4
Tbio
Novelty:  0.01326511
p_int:  0.998564488
p_ni:  0.001435512
Score:  0.179
Data Source:  BioPlex,STRINGDB
CDCA2
Tbio
Novelty:  0.04666018
p_int:  0.997239258
p_ni:  0.002712398
p_wrong:  0.000048344
Score:  0.179
Data Source:  BioPlex,STRINGDB
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
p_int:  0.995483833
p_ni:  0.004516167
Score:  0.307
Data Source:  BioPlex,STRINGDB
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.994484947
p_ni:  0.005514739
p_wrong:  3.14e-7
Score:  0.514
Data Source:  BioPlex,STRINGDB
GLE1
Tbio
Novelty:  0.01655737
p_int:  0.994288297
p_ni:  0.005711649
p_wrong:  5.3e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
PITX2
Tbio
Family:  TF
Novelty:  0.00216568
p_int:  0.99046107
p_ni:  4.17e-7
p_wrong:  0.009538513
Score:  0.193
Data Source:  BioPlex,STRINGDB
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.987502169
p_ni:  0.012497831
Score:  0.18
Data Source:  BioPlex,STRINGDB
NSMCE4A
Tdark
Novelty:  0.45550673
p_int:  0.980484622
p_ni:  0.019515367
p_wrong:  1.1e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
86.8
monocyte percentage of leukocytes
2
3
3
84.3
platelet crit
1
2
2
77.6
mean platelet volume
2
2
2
76.2
self reported educational attainment
3
3
3
5.9
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
86.8
monocyte percentage of leukocytes
3
84.3
platelet crit
2
77.6
mean platelet volume
2
76.2
self reported educational attainment
3
5.9
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104815
15936
Dog
immediate early response 2
VGNC:41868
484917
Horse
immediate early response 2
VGNC:18941
100063913
Cow
immediate early response 2
VGNC:30038
525380
Pig
immediate early response 2
100525209
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
immediate early response 2
Horse
immediate early response 2
Cow
immediate early response 2
Pig
immediate early response 2
Publication Statistics
PubMed Score 28.38
PubMed score by year
PubTator Score 11.05
PubTator score by year
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Related Publications
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PMID
Year
Title