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Tbio
IDUA
Alpha-L-iduronidase

Protein Summary
Description
This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247933
  • ENSP00000247933
  • ENSG00000127415

Symbol
  • IDA
  • MPS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
cellular component
0.77
transcription factor binding site profile
0.72
phenotype
0.69
PubMedID
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.11   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.11   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.998595139
p_ni:  0.000001655
p_wrong:  0.001403207
Score:  0.188
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.990684104
p_ni:  0.002151234
p_wrong:  0.007164662
Data Source:  BioPlex
IDS
Tbio
Family:  Enzyme
Novelty:  0.00733996
Score:  0.97
Data Source:  STRINGDB
SGSH
Tbio
Family:  Enzyme
Novelty:  0.00670111
Score:  0.968
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.966
Data Source:  STRINGDB
HEXA
Tchem
Family:  Enzyme
Novelty:  0.01134783
Score:  0.932
Data Source:  STRINGDB
HYAL1
Tbio
Family:  Enzyme
Novelty:  0.00756819
Score:  0.923
Data Source:  STRINGDB
SPAM1
Tbio
Family:  Enzyme
Novelty:  0.0041597
Score:  0.92
Data Source:  STRINGDB
HYAL4
Tbio
Family:  Enzyme
Novelty:  0.10127674
Score:  0.912
Data Source:  STRINGDB
HYAL3
Tbio
Family:  Enzyme
Novelty:  0.14284007
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
CS/DS degradation (R-HSA-2024101)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
CS/DS degradation
Chondroitin sulfate/dermatan sulfate metabolism
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
13
21
99.7
8
5
2
1.2
97.5
waist-hip ratio
3
9
9
91.1
BMI-adjusted waist-hip ratio
3
8
9
90.6
bone density
4
5
5
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
21
99.7
2
1.2
97.5
waist-hip ratio
9
91.1
BMI-adjusted waist-hip ratio
9
90.6
bone density
5
90.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
iduronidase, alpha-L-
461056
Mouse
MGI:96418
15932
Rat
RGD:1310943
360904
Dog
iduronidase, alpha-L-
VGNC:41867
100505382
Horse
iduronidase, alpha-L-
VGNC:18940
100146682
Species
Name
OMA
EggNOG
Inparanoid
Chimp
iduronidase, alpha-L-
Mouse
Rat
Dog
iduronidase, alpha-L-
Horse
iduronidase, alpha-L-
Publication Statistics
PubMed Score 389.11
PubMed score by year
PubTator Score 429.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title