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Tbio
IDS
Iduronate 2-sulfatase

Protein Summary
Description
Required for the lysosomal degradation of heparan sulfate and dermatan sulfate. This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340855
  • ENSP00000339801
  • ENSG00000010404
  • ENST00000370441
  • ENSP00000359470
  • ENST00000466323
  • ENSP00000418264

Symbol
  • SIDS
  • MPS2
  • SIDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.95
small molecule perturbation
0.93
virus perturbation
0.79
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.49   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.49   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.999940514
p_ni:  0.000059456
p_wrong:  3.1e-8
Data Source:  BioPlex
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.999931869
p_ni:  0.00006813
Score:  0.872
Data Source:  BioPlex,STRINGDB
GALNT18
Tbio
Family:  Enzyme
Novelty:  0.15496205
p_int:  0.999926843
p_ni:  0.000072884
p_wrong:  2.73e-7
Score:  0.328
Data Source:  BioPlex,STRINGDB
FBXO21
Tbio
Novelty:  0.2186203
p_int:  0.999451149
p_ni:  0.000548847
p_wrong:  4e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.997839679
p_ni:  0.002160321
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.994256751
p_ni:  0.005740598
p_wrong:  0.000002651
Data Source:  BioPlex
MESD
Tbio
Novelty:  0.02639297
p_int:  0.987469221
p_ni:  0.012528716
p_wrong:  0.000002063
Score:  0.181
Data Source:  BioPlex,STRINGDB
CERCAM
Tdark
Family:  Enzyme
Novelty:  0.33392502
p_int:  0.986044584
p_ni:  0.013955416
Data Source:  BioPlex
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.97235475
p_ni:  0.02764525
Data Source:  BioPlex
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.970302331
p_ni:  0.029697659
p_wrong:  1e-8
Score:  0.52
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
CS/DS degradation (R-HSA-2024101)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
CS/DS degradation
Chondroitin sulfate/dermatan sulfate metabolism
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96417
15931
Dog
iduronate 2-sulfatase
VGNC:54165
492194
Cow
iduronate 2-sulfatase
541272
Pig
iduronate 2-sulfatase
100512880
Opossum
iduronate 2-sulfatase
100025173
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
iduronate 2-sulfatase
Cow
iduronate 2-sulfatase
Pig
iduronate 2-sulfatase
Opossum
iduronate 2-sulfatase
Publication Statistics
PubMed Score 128.49
PubMed score by year
PubTator Score 1206.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title