Tchem IDO2 Indoleamine 2,3-dioxygenase 2

Protein Summary

Description

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]

Uniprot Accession IDs

• Q6ZQW0
• A4UD41
• F5H5G0
• IDO-2

Gene Name

• IDO2

Ensembl ID

• ENST00000502986
• ENSP00000443432
• ENSG00000188676

Symbol

• INDOL1
• INDOL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.59
pathway	0.59
cell line	0.57
molecular function	0.56
tissue	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.08   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 361   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.08   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0