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Tchem
IDO1
Indoleamine 2,3-dioxygenase 1

Protein Summary
Description
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000518237
  • ENSP00000430950
  • ENSG00000131203
  • ENST00000522495
  • ENSP00000430505

Symbol
  • IDO
  • INDO
  • IDO
  • INDO
  • IDO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
virus perturbation
0.94
PubMedID
0.81
cell type or tissue
0.76
gene perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1057.96   (req: < 5)
Gene RIFs: 332   (req: <= 3)
Antibodies: 855   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1057.96   (req: >= 5)
Gene RIFs: 332   (req: > 3)
Antibodies: 855   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 752
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (198)
TDO2
Tchem
Family:  Enzyme
Novelty:  0.00115832
Score:  0.985
Data Source:  STRINGDB
KYNU
Tchem
Family:  Enzyme
Novelty:  0.01372383
Score:  0.972
Data Source:  STRINGDB
TPH1
Tclin
Family:  Enzyme
Novelty:  0.00098637
Score:  0.946
Data Source:  STRINGDB
AFMID
Tbio
Family:  Enzyme
Novelty:  0.02027656
Score:  0.945
Data Source:  STRINGDB
INMT
Tchem
Family:  Enzyme
Novelty:  0.01771517
Score:  0.933
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.926
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.925
Data Source:  STRINGDB
CYP1B1
Tchem
Novelty:  0.00090917
Score:  0.925
Data Source:  STRINGDB
TPH2
Tchem
Family:  Enzyme
Novelty:  0.00265377
Score:  0.921
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.917
Data Source:  STRINGDB
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
indoleamine 2,3-dioxygenase 1
VGNC:3011
464134
Macaque
indoleamine 2,3-dioxygenase 1
574370
Mouse
MGI:96416
15930
Rat
RGD:619989
66029
Dog
indoleamine 2,3-dioxygenase 1
VGNC:41865
475574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
indoleamine 2,3-dioxygenase 1
Macaque
indoleamine 2,3-dioxygenase 1
Mouse
Rat
Dog
indoleamine 2,3-dioxygenase 1
Publication Statistics
PubMed Score 1057.96
PubMed score by year
PubTator Score 1298.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title