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Tbio
IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Protein Summary
Description
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217901
  • ENSP00000217901
  • ENSG00000067829
  • ENST00000370092
  • ENSP00000359110

Symbol
  • H-IDHG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.96
histone modification site profile
0.92
transcription factor perturbation
0.88
co-expressed gene
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.44   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.44   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
IDH3B
Tbio
Family:  Enzyme
Novelty:  0.04326765
p_int:  1
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
IDH3A
Tbio
Family:  Enzyme
Novelty:  0.02027198
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.793372201
p_ni:  0.206627799
Score:  0.917
Data Source:  BioPlex,STRINGDB
ACO2
Tbio
Family:  Enzyme
Novelty:  0.00276725
Score:  0.998
Data Source:  STRINGDB
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
Score:  0.998
Data Source:  STRINGDB
IDH1
Tclin
Family:  Enzyme
Novelty:  0.0004831
Score:  0.995
Data Source:  STRINGDB
TIMM44
Tbio
Family:  Enzyme
Novelty:  0.020862
Score:  0.982
Data Source:  STRINGDB
OGDH
Tbio
Family:  Enzyme
Novelty:  0.00674601
Score:  0.975
Data Source:  STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.968
Data Source:  STRINGDB
OGDHL
Tbio
Family:  Enzyme
Novelty:  0.05079572
Score:  0.963
Data Source:  STRINGDB
Pathways (13)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Mitochondrial protein import
Reactome
Protein localization
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Mitochondrial protein import
Protein localization
Pyruvate metabolism and Citric Acid (TCA) cycle
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
40.4
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
isocitrate dehydrogenase 3 (NAD(+)) gamma
VGNC:14690
741179
Macaque
isocitrate dehydrogenase 3 (NAD(+)) gamma
698558
Mouse
MGI:1099463
15929
Rat
RGD:2863
25179
Dog
isocitrate dehydrogenase 3 (NAD(+)) gamma
481081
Species
Name
OMA
EggNOG
Inparanoid
Chimp
isocitrate dehydrogenase 3 (NAD(+)) gamma
Macaque
isocitrate dehydrogenase 3 (NAD(+)) gamma
Mouse
Rat
Dog
isocitrate dehydrogenase 3 (NAD(+)) gamma
Publication Statistics
PubMed Score 14.44
PubMed score by year
PubTator Score 2.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title