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Tbio
IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Protein Summary
Description
Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380843
  • ENSP00000370223
  • ENSG00000101365
  • ENST00000380851
  • ENSP00000370232

Symbol
  • RP46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
disease perturbation
0.9
co-expressed gene
0.89
gene perturbation
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.54   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.54   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (153)
IDH3G
Tbio
Family:  Enzyme
Novelty:  0.04861242
p_int:  1
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
IDH3A
Tbio
Family:  Enzyme
Novelty:  0.02027198
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GDF3
Tbio
Novelty:  0.02003647
p_int:  0.999154406
p_ni:  0.000845594
Score:  0.513
Data Source:  BioPlex,STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.99145614
p_ni:  0.00854386
Score:  0.429
Data Source:  BioPlex,STRINGDB
GPD1
Tbio
Family:  Enzyme
Novelty:  0.00584133
p_int:  0.984199064
p_ni:  0.015800936
Score:  0.454
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.951634479
p_ni:  0.048365521
Data Source:  BioPlex
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
Score:  0.997
Data Source:  STRINGDB
IDH1
Tclin
Family:  Enzyme
Novelty:  0.0004831
Score:  0.995
Data Source:  STRINGDB
ACO2
Tbio
Family:  Enzyme
Novelty:  0.00276725
Score:  0.994
Data Source:  STRINGDB
OGDH
Tbio
Family:  Enzyme
Novelty:  0.00674601
Score:  0.977
Data Source:  STRINGDB
Pathways (16)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
isocitrate dehydrogenase 3 (NAD(+)) beta
VGNC:9872
458048
Macaque
isocitrate dehydrogenase 3 (NAD(+)) beta
716726
Mouse
MGI:2158650
170718
Rat
RGD:621881
94173
Dog
isocitrate dehydrogenase 3 (NAD(+)) beta
477177
Species
Name
OMA
EggNOG
Inparanoid
Chimp
isocitrate dehydrogenase 3 (NAD(+)) beta
Macaque
isocitrate dehydrogenase 3 (NAD(+)) beta
Mouse
Rat
Dog
isocitrate dehydrogenase 3 (NAD(+)) beta
Publication Statistics
PubMed Score 20.54
PubMed score by year
PubTator Score 3.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title