Tclin IDH2 Isocitrate dehydrogenase [NADP], mitochondrial

Protein Summary

Description

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• P48735
• B2R6L6
• B4DFL2
• Q96GT3
• IDH

Gene Name

• IDH2

Ensembl ID

• ENST00000330062
• ENSP00000331897
• ENSG00000182054
• ENST00000540499
• ENSP00000446147

Symbol

• IDH
• IDP
• IDHM
• IDPM
• ICD-M
• D2HGA2
• mNADP-IDH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.97
biological term	0.94
PubMedID	0.83
interacting protein	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 921.36   (req: < 5)

Gene RIFs: 400   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 921.36   (req: >= 5)

Gene RIFs: 400   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 103

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1