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Tbio
ID2
DNA-binding protein inhibitor ID-2

Protein Summary
Description
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. The protein encoded by this gene belongs to the inhi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234091
  • ENSP00000234091
  • ENSG00000115738
  • ENST00000331129
  • ENSP00000385465
  • ENST00000396290
  • ENSP00000379585

Symbol
  • BHLHB26
  • GIG8
  • ID2A
  • ID2H
  • bHLHb26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
1
PubMedID
1
transcription factor perturbation
1
kinase perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.92   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 399   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.92   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
p_int:  0.999999936
p_ni:  6.4e-8
Score:  0.881
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999999882
p_ni:  1.18e-7
Score:  0.89
Data Source:  BioPlex,STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
p_int:  0.999997212
p_ni:  0.000002788
Score:  0.831
Data Source:  BioPlex,STRINGDB
ID4
Tbio
Family:  TF
Novelty:  0.00399089
p_int:  0.99994069
p_ni:  0.000057752
p_wrong:  0.000001558
Score:  0.703
Data Source:  BioPlex,STRINGDB
PHF3
Tbio
Family:  Epigenetic
Novelty:  0.08898449
p_int:  0.999518134
p_ni:  0.000481855
p_wrong:  1.2e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
WBP11
Tbio
Novelty:  0.03891455
p_int:  0.994659898
p_ni:  0.005323416
p_wrong:  0.000016686
Score:  0.177
Data Source:  BioPlex,STRINGDB
CLASP2
Tbio
Novelty:  0.0353308
p_int:  0.994144077
p_ni:  0.004588968
p_wrong:  0.001266954
Score:  0.181
Data Source:  BioPlex,STRINGDB
YY1
Tbio
Family:  TF
Novelty:  0.00120891
p_int:  0.981985099
p_ni:  0.011023875
p_wrong:  0.006991026
Score:  0.38
Data Source:  BioPlex,STRINGDB
ZGPAT
Tbio
Family:  Epigenetic
Novelty:  0.16971298
p_int:  0.959393717
p_ni:  0.040311538
p_wrong:  0.000294744
Data Source:  BioPlex
MACF1
Tbio
Novelty:  0.0166336
p_int:  0.958664885
p_ni:  0.041335115
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
TGF-beta signaling pathway
KEGG
Signaling pathways regulating pluripotency of stem cells
KEGG
Hippo signaling pathway
KEGG
Transcriptional misregulation in cancer
Name
Explore in Pharos
Explore in Source
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells
Hippo signaling pathway
Transcriptional misregulation in cancer
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (61)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
2
4
88.7
reticulocyte count
7
2
7
88.6
electrocardiography
1
2
34
76.5
mean reticulocyte volume
1
1
1
42.1
red blood cell distribution width
4
1
4
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
88.7
reticulocyte count
7
88.6
electrocardiography
34
76.5
mean reticulocyte volume
1
42.1
red blood cell distribution width
4
42.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
inhibitor of DNA binding 2
693394
Mouse
MGI:96397
15902
Rat
RGD:2859
25587
Horse
inhibitor of DNA binding 2
VGNC:51321
100057240
Cow
inhibitor of DNA binding 2
505025
Species
Name
OMA
EggNOG
Inparanoid
Macaque
inhibitor of DNA binding 2
Mouse
Rat
Horse
inhibitor of DNA binding 2
Cow
inhibitor of DNA binding 2
Publication Statistics
PubMed Score 408.92
PubMed score by year
PubTator Score 262.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title