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Tbio
ID1
DNA-binding protein inhibitor ID-1

Protein Summary
Description
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and di ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376105
  • ENSP00000365273
  • ENSG00000125968
  • ENST00000376112
  • ENSP00000365280

Symbol
  • BHLHB24
  • ID
  • ID
  • bHLHb24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
1
virus perturbation
1
transcription factor perturbation
0.98
small molecule perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 689.98   (req: < 5)
Gene RIFs: 218   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 689.98   (req: >= 5)
Gene RIFs: 218   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.924
Data Source:  BioPlex,STRINGDB
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.947
Data Source:  STRINGDB
ETS1
Tbio
Family:  TF
Novelty:  0.00105233
Score:  0.94
Data Source:  STRINGDB
ETS2
Tbio
Family:  TF
Novelty:  0.00327214
Score:  0.938
Data Source:  Reactome,STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.918
Data Source:  STRINGDB
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.904
Data Source:  STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
Score:  0.875
Data Source:  STRINGDB
ASCL3
Tbio
Family:  TF
Novelty:  0.07049962
Score:  0.842
Data Source:  STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.825
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.8
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
Pathways (18)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oncogene Induced Senescence
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Oncogene Induced Senescence
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
90.3
eosinophil percentage of leukocytes
1
1
1
78.4
heel bone mineral density
2
2
2
69.1
putamen volume
1
1
0
8.1
66
caudate nucleus volume
1
1
0
6.8
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
90.3
eosinophil percentage of leukocytes
1
78.4
heel bone mineral density
2
69.1
putamen volume
0
8.1
66
caudate nucleus volume
0
6.8
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibitor of DNA binding 1, HLH protein
VGNC:9871
469912
Macaque
inhibitor of DNA binding 1, HLH protein
713160
Mouse
MGI:96396
15901
Rat
RGD:2858
25261
Horse
inhibitor of DNA binding 1, HLH protein
VGNC:18934
100068419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibitor of DNA binding 1, HLH protein
Macaque
inhibitor of DNA binding 1, HLH protein
Mouse
Rat
Horse
inhibitor of DNA binding 1, HLH protein
Publication Statistics
PubMed Score 689.98
PubMed score by year
PubTator Score 403.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title