You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ICMT
Protein-S-isoprenylcysteine O-methyltransferase

Protein Summary
Description
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343813
  • ENSP00000343552
  • ENSG00000116237

Symbol
  • PCCMT
  • PCMT
  • PPMT
  • PCCMT
  • HSTE14
  • MST098
  • MSTP098
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
microRNA
0.71
transcription factor binding site profile
0.67
biological process
0.65
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.04   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.04   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 80
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0