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Tchem
ICMT
Protein-S-isoprenylcysteine O-methyltransferase

Protein Summary
Description
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343813
  • ENSP00000343552
  • ENSG00000116237

Symbol
  • PCCMT
  • PCMT
  • PPMT
  • PCCMT
  • HSTE14
  • MST098
  • MSTP098
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
microRNA
0.71
transcription factor binding site profile
0.67
biological process
0.65
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.12   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.12   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 80
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (64)
GCA
Tbio
Novelty:  0.01485875
p_int:  0.992881276
p_ni:  0.007111013
p_wrong:  0.000007711
Score:  0.187
Data Source:  BioPlex,STRINGDB
RAD51D
Tbio
Novelty:  0.01422516
p_int:  0.982396043
p_ni:  0.017603957
Score:  0.193
Data Source:  BioPlex,STRINGDB
PCCA
Tbio
Family:  Enzyme
Novelty:  0.00515417
p_int:  0.971436672
p_ni:  0.028562764
p_wrong:  5.65e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
STXBP3
Tbio
Novelty:  0.03346737
p_int:  0.882079822
p_ni:  0.117920178
Score:  0.205
Data Source:  BioPlex,STRINGDB
OXSR1
Tbio
Family:  Kinase
Novelty:  0.11142923
p_int:  0.866246125
p_ni:  0.133753875
Score:  0.199
Data Source:  BioPlex,STRINGDB
PPM1E
Tbio
Family:  Enzyme
Novelty:  0.08964901
p_int:  0.763978146
p_ni:  0.236021853
p_wrong:  1e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
RCE1
Tchem
Family:  Enzyme
Novelty:  0.01209847
Score:  0.996
Data Source:  STRINGDB
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
Score:  0.991
Data Source:  STRINGDB
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
Score:  0.81
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.803
Data Source:  STRINGDB
Pathways (52)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
6
4
3
1.7
92.5
TPE interval measurement
1
1
3
78.5
electrocardiography
1
1
46
78.1
T wave morphology measurement
2
1
2
49.5
metabolite measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
3
1.7
92.5
TPE interval measurement
3
78.5
electrocardiography
46
78.1
T wave morphology measurement
2
49.5
metabolite measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
isoprenylcysteine carboxyl methyltransferase
VGNC:1266
469782
Macaque
isoprenylcysteine carboxyl methyltransferase
702925
Mouse
MGI:1888594
57295
Rat
RGD:621618
170818
Horse
isoprenylcysteine carboxyl methyltransferase
VGNC:18932
100059680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
isoprenylcysteine carboxyl methyltransferase
Macaque
isoprenylcysteine carboxyl methyltransferase
Mouse
Rat
Horse
isoprenylcysteine carboxyl methyltransferase
Publication Statistics
PubMed Score 155.12
PubMed score by year
PubTator Score 81.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title