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Tchem
ICK
Serine/threonine-protein kinase ICK

Protein Summary
Description
Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350082
  • ENSP00000263043
  • ENSG00000112144
  • ENST00000356971
  • ENSP00000349458

Symbol
  • KIAA0936
  • ECO
  • MRK
  • LCK2
  • EJM10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
drug perturbation
0.87
transcription factor binding site profile
0.85
small molecule perturbation
0.79
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.23   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.23   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (66)
CDK16
Tchem
Family:  Kinase
Novelty:  0.02579684
p_int:  0.999953568
p_ni:  5e-9
p_wrong:  0.000046427
Score:  0.42
Data Source:  BioPlex,STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  0.998287035
p_ni:  0.000010115
p_wrong:  0.00170285
Score:  0.195
Data Source:  BioPlex,STRINGDB
CDK14
Tchem
Family:  Kinase
Novelty:  0.02074169
p_int:  0.995331539
p_ni:  0.000075454
p_wrong:  0.004593007
Score:  0.401
Data Source:  BioPlex,STRINGDB
FAM217B
Tdark
Novelty:  4.03122155
p_int:  0.993492677
p_ni:  0.004526865
p_wrong:  0.001980458
Score:  0.169
Data Source:  BioPlex,STRINGDB
DEPDC1
Tbio
Novelty:  0.04255829
p_int:  0.990925844
p_ni:  0.004496295
p_wrong:  0.004577861
Score:  0.175
Data Source:  BioPlex,STRINGDB
MSI2
Tbio
Novelty:  0.01716735
p_int:  0.989434814
p_ni:  0.005215805
p_wrong:  0.005349381
Score:  0.2
Data Source:  BioPlex,STRINGDB
FCGR3B
Tbio
Novelty:  0.000429
p_int:  0.987816485
p_ni:  0.010481735
p_wrong:  0.00170178
Score:  0.186
Data Source:  BioPlex,STRINGDB
SLC35A1
Tbio
Family:  Transporter
Novelty:  0.02071929
p_int:  0.983232285
p_ni:  0.014527947
p_wrong:  0.002239768
Score:  0.345
Data Source:  BioPlex,STRINGDB
LSM14B
Tdark
Novelty:  0.31832554
p_int:  0.97006277
p_ni:  0.000111681
p_wrong:  0.029825548
Score:  0.187
Data Source:  BioPlex,STRINGDB
A4GNT
Tbio
Family:  Enzyme
Novelty:  0.08971876
p_int:  0.967140651
p_ni:  0.001110951
p_wrong:  0.031748397
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
70.4
smoking initiation
1
1
1
47.7
age at first sexual intercourse measurement
1
1
1
38.8
smoking behaviour measurement
1
1
1
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
70.4
smoking initiation
1
47.7
age at first sexual intercourse measurement
1
38.8
smoking behaviour measurement
1
6.4
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intestinal cell kinase
VGNC:12641
462772
Macaque
intestinal cell kinase
711865
Mouse
MGI:1934157
56542
Rat
RGD:71050
84411
Dog
intestinal cell kinase
VGNC:41860
481843
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intestinal cell kinase
Macaque
intestinal cell kinase
Mouse
Rat
Dog
intestinal cell kinase
Publication Statistics
PubMed Score 124.23
PubMed score by year
PubTator Score 90.60
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title