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Tbio
ICE2
Little elongation complex subunit 2

Protein Summary
Description
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261520
  • ENSP00000261520
  • ENSG00000128915
  • ENST00000558181
  • ENSP00000453593
  • ENST00000560668
  • ENSP00000453303

Symbol
  • BRCC1
  • NARG2
  • BRCC1
  • NARG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
hub protein
0.79
histone modification site profile
0.78
tissue
0.68
transcription factor
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.69   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.69   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.999999722
p_ni:  2.7e-7
p_wrong:  8e-9
Score:  0.334
Data Source:  BioPlex,STRINGDB
MUC5B
Tbio
Novelty:  0.000832
p_int:  0.999999606
p_ni:  3.94e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
p_int:  0.99999908
p_ni:  3.91e-7
p_wrong:  5.29e-7
Score:  0.311
Data Source:  BioPlex,STRINGDB
ELL3
Tbio
Family:  Enzyme
Novelty:  0.18245631
p_int:  0.999996364
p_ni:  0.000003636
p_wrong:  1e-9
Score:  0.948
Data Source:  BioPlex,Reactome,STRINGDB
BPIFA1
Tbio
Novelty:  0.00586117
p_int:  0.999978199
p_ni:  0.000014486
p_wrong:  0.000007315
Score:  0.209
Data Source:  BioPlex,STRINGDB
LTF
Tbio
Novelty:  0.00114254
p_int:  0.999658439
p_ni:  0.000341561
Data Source:  BioPlex
PIGR
Tbio
Novelty:  0.0025812
p_int:  0.999562364
p_ni:  0.000437632
p_wrong:  4e-9
Data Source:  BioPlex
SERPINA1
Tbio
Novelty:  0.00014098
p_int:  0.999387966
p_ni:  0.000612023
p_wrong:  1.1e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.998920482
p_ni:  0.001079506
p_wrong:  1.2e-8
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.998518208
p_ni:  0.001465006
p_wrong:  0.000016786
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
3
3
95.3
balding measurement
2
2
2
69.1
age at menarche
1
1
1
58.4
serum albumin measurement
1
1
1
57.8
puberty onset measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
95.3
balding measurement
2
69.1
age at menarche
1
58.4
serum albumin measurement
1
57.8
puberty onset measurement
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interactor of little elongation complex ELL subunit 2
VGNC:1934
453489
Macaque
interactor of little elongation complex ELL subunit 2
706347
Mouse
MGI:2135947
93697
Rat
RGD:1585038
691379
Dog
interactor of little elongation complex ELL subunit 2
VGNC:41859
608993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interactor of little elongation complex ELL subunit 2
Macaque
interactor of little elongation complex ELL subunit 2
Mouse
Rat
Dog
interactor of little elongation complex ELL subunit 2
Publication Statistics
PubMed Score 27.69
PubMed score by year
PubTator Score 8.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title