Tchem ICAM1 Intercellular adhesion molecule 1

Protein Summary

Description

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P05362
• B2R6M3
• Q5NKV7
• Q96B50
• ICAM-1

Gene Name

• ICAM1

Ensembl ID

• ENST00000264832
• ENSP00000264832
• ENSG00000090339

Symbol

• BB2
• CD54
• P3.58

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
transcription factor perturbation	0.98
virus perturbation	0.95
gene perturbation	0.94

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11063.69   (req: < 5)

Gene RIFs: 1071   (req: <= 3)

Antibodies: 2725   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11063.69   (req: >= 5)

Gene RIFs: 1071   (req: > 3)

Antibodies: 2725   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 139

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1