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Tbio
IBTK
Inhibitor of Bruton tyrosine kinase

Protein Summary
Description
Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306270
  • ENSP00000305721
  • ENSG00000005700
  • ENST00000635454
  • ENSP00000489389
  • ENSG00000283068

Symbol
  • BTKI
  • KIAA1417
  • BTKI
  • BTBD26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.87
kinase perturbation
0.84
cell line
0.7
biological process
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.6   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.6   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
EIF4A1
Tchem
Novelty:  0.00269994
p_int:  1
Score:  0.518
Data Source:  BioPlex,STRINGDB
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999999871
p_ni:  1.9e-8
p_wrong:  1.11e-7
Data Source:  BioPlex
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999997597
p_ni:  0.000002403
Score:  0.781
Data Source:  BioPlex,STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
Score:  0.977
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.929
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.923
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.918
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.909
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.909
Data Source:  STRINGDB
BLNK
Tbio
Novelty:  0.00351169
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
3
78
intraocular pressure measurement
1
1
1
72.6
corneal topography
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3
78
intraocular pressure measurement
1
72.6
corneal topography
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibitor of Bruton tyrosine kinase
VGNC:7187
462849
Macaque
inhibitor of Bruton tyrosine kinase
693559
Mouse
MGI:1918677
108837
Rat
RGD:1311697
315858
Dog
inhibitor of Bruton tyrosine kinase
VGNC:41853
481897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibitor of Bruton tyrosine kinase
Macaque
inhibitor of Bruton tyrosine kinase
Mouse
Rat
Dog
inhibitor of Bruton tyrosine kinase
Publication Statistics
PubMed Score 26.60
PubMed score by year
PubTator Score 10.95
PubTator score by year
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Related Publications
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PMID
Year
Title