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Tchem
IARS2
Isoleucine--tRNA ligase, mitochondrial

Protein Summary
Description
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
protein domain
0.99
molecular function
0.94
tissue sample
0.7
tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.53   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.53   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (173)
ASB8
Tdark
Novelty:  0.44680949
p_int:  0.999999749
p_ni:  2.51e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.99924068
p_ni:  0.00075932
Data Source:  BioPlex
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.995818336
p_ni:  0.004176554
p_wrong:  0.00000511
Score:  0.16
Data Source:  BioPlex,STRINGDB
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
p_int:  0.966585963
p_ni:  0.016335564
p_wrong:  0.017078473
Score:  0.208
Data Source:  BioPlex,STRINGDB
CELF5
Tbio
Novelty:  0.04733002
p_int:  0.942956467
p_ni:  0.057043533
Score:  0.158
Data Source:  BioPlex,STRINGDB
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  0.904682844
p_ni:  0.0867251
p_wrong:  0.008592056
Data Source:  BioPlex
ESPL1
Tbio
Family:  Enzyme
Novelty:  0.00346666
p_int:  0.899207793
p_ni:  0.100792206
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
ASPM
Tbio
Novelty:  0.00599688
p_int:  0.891330785
p_ni:  0.108669215
Score:  0.352
Data Source:  BioPlex,STRINGDB
MBNL1
Tbio
Novelty:  0.00441241
p_int:  0.879989696
p_ni:  0.120010304
Score:  0.169
Data Source:  BioPlex,STRINGDB
TMEM70
Tbio
Novelty:  0.03111438
p_int:  0.878877247
p_ni:  0.121122753
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
1
3
71.2
ferritin measurement
1
1
1
59
smoking status measurement
1
1
1
17.8
glomerular filtration rate
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
71.2
ferritin measurement
1
59
smoking status measurement
1
17.8
glomerular filtration rate
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919586
381314
Dog
isoleucyl-tRNA synthetase 2, mitochondrial
VGNC:41850
478963
Horse
isoleucyl-tRNA synthetase 2, mitochondrial
VGNC:18922
100049915
Cow
isoleucyl-tRNA synthetase 2, mitochondrial
VGNC:30019
533057
Opossum
isoleucyl-tRNA synthetase 2, mitochondrial
100024337
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
isoleucyl-tRNA synthetase 2, mitochondrial
Horse
isoleucyl-tRNA synthetase 2, mitochondrial
Cow
isoleucyl-tRNA synthetase 2, mitochondrial
Opossum
isoleucyl-tRNA synthetase 2, mitochondrial
Publication Statistics
PubMed Score 114.53
PubMed score by year
PubTator Score 11.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title