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Tbio
IAPP
Islet amyloid polypeptide

Protein Summary
Description
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240652
  • ENSP00000240652
  • ENSG00000121351
  • ENST00000539393
  • ENSP00000437357

Symbol
  • DAP
  • IAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
protein domain
0.73
cell line
0.62
gene perturbation
0.62
disease
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2233.9   (req: < 5)
Gene RIFs: 244   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2233.9   (req: >= 5)
Gene RIFs: 244   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (193)
RAMP3
Tclin
Novelty:  0.01616194
Score:  0.987
Data Source:  Reactome,STRINGDB
RAMP2
Tclin
Novelty:  0.01086538
Score:  0.986
Data Source:  Reactome,STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
Score:  0.986
Data Source:  Reactome,STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.985
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.985
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.984
Data Source:  STRINGDB
ADM
Tbio
Novelty:  0.0004958
Score:  0.983
Data Source:  STRINGDB
CALCB
Tclin
Novelty:  0.02069808
Score:  0.982
Data Source:  STRINGDB
CALCR
Tclin
Family:  GPCR
Novelty:  0.00112487
Score:  0.975
Data Source:  Reactome,STRINGDB
PDX1
Tbio
Family:  TF
Novelty:  0.00232117
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
Developmental Biology
Reactome
G alpha (s) signalling events
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
Developmental Biology
G alpha (s) signalling events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
10
17
98.8
serum metabolite measurement
1
1
4
84.4
serum gamma-glutamyl transferase measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
17
98.8
serum metabolite measurement
4
84.4
serum gamma-glutamyl transferase measurement
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
islet amyloid polypeptide
VGNC:8421
741937
Macaque
islet amyloid polypeptide [Source:HGNC Symbol;Acc:HGNC:5329]
Mouse
MGI:96382
15874
Rat
RGD:2854
24476
Dog
islet amyloid polypeptide
VGNC:41848
403909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
islet amyloid polypeptide
Macaque
islet amyloid polypeptide [Source:HGNC Symbol;Acc:HGNC:5329]
Mouse
Rat
Dog
islet amyloid polypeptide
Publication Statistics
PubMed Score 2233.90
PubMed score by year
PubTator Score 1495.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title