Protein Summary
Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq, Jul 2008]
- ENST00000223026
- ENSP00000223026
- ENSG00000106302
- ENST00000476325
- ENSP00000417186
- CSHY
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.71 | ||
protein domain | 0.58 | ||
gene perturbation | 0.57 | ||
cell line | 0.5 | ||
tissue | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.89 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.89 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (34)
GAPDHS
Family: Enzyme
Novelty: 0.00885959
p_int: 0.960097116
p_ni: 0.039902877
p_wrong: 7e-9
Score: 0.351
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
KEGG (2)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Metabolic pathways | ||||
KEGG | Glycosaminoglycan degradation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolic pathways | ||||
Glycosaminoglycan degradation | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 3 | 5 | 4 | 4.1 | 97.5 | ||||
platelet crit | 2 | 4 | 4 | 95.3 | |||||
mean platelet volume | 3 | 4 | 4 | 93.6 | |||||
reticulocyte count | 4 | 5 | 6 | 91.4 | |||||
reticulocyte measurement | 2 | 3 | 4 | 84.9 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 4 | 4.1 | 97.5 | ||||
platelet crit | 4 | 95.3 | |||||
mean platelet volume | 4 | 93.6 | |||||
reticulocyte count | 6 | 91.4 | |||||
reticulocyte measurement | 4 | 84.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hyaluronoglucosaminidase 4 | VGNC:14026 | 472497 | |||||
Macaque | hyaluronidase-4 | 696128 | ||||||
Mouse | MGI:1924292 | 77042 | ||||||
Rat | RGD:1303194 | 404783 | ||||||
Dog | hyaluronoglucosaminidase 4 | VGNC:41844 | 475212 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hyaluronoglucosaminidase 4 | |||||
Macaque | hyaluronidase-4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hyaluronoglucosaminidase 4 | |||||
Publication Statistics
PubMed Score 7.89
PubMed score by year
PubTator Score 3.40
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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