Tbio HYAL2 Hyaluronidase-2

Protein Summary

Description

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q12891
• B3KRZ2
• O15177
• Q9BW29
• Hyal-2

Gene Name

• HYAL2

Ensembl ID

• ENST00000357750
• ENSP00000350387
• ENSG00000068001
• ENST00000395139
• ENSP00000378571
• ENST00000442581
• ENSP00000406657
• ENST00000447092
• ENSP00000401853

Symbol

• LUCA2
• LUCA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.94
cellular component	0.87
transcription factor binding site profile	0.82
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Receptor / Hyaluronidase-2

Protein / Hydrolase / Glycosidase / Hyaluronidase-2

DTO Classes

Protein / Enzyme / Hydrolase / Glycosidase / Hyaluronidase-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.38   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 254   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.38   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0