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Tbio
HYAL1
Hyaluronidase-1

Protein Summary
Description
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266031
  • ENSP00000266031
  • ENSG00000114378
  • ENST00000320295
  • ENSP00000346068
  • ENST00000395143
  • ENSP00000378575
  • ENST00000395144
  • ENSP00000378576
  • ENST00000447605
  • ENSP00000390149
  • ENST00000457214
  • ENSP00000393358
  • ENST00000618175
  • ENSP00000477903

Symbol
  • LUCA1
  • MPS9
  • NAT6
  • LUCA1
  • HYAL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
cellular component
0.72
tissue sample
0.7
molecular function
0.63
pathway
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.62   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.62   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.93601671
p_ni:  0.06398329
Score:  0.179
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.891910557
p_ni:  0.108089443
Score:  0.183
Data Source:  BioPlex,STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.855287744
p_ni:  0.144712256
Score:  0.656
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.826827995
p_ni:  0.173172005
Score:  0.185
Data Source:  BioPlex,STRINGDB
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.816628838
p_ni:  0.169770267
p_wrong:  0.013600895
Score:  0.542
Data Source:  BioPlex,STRINGDB
TUBA1B
Tchem
Novelty:  0.02465964
p_int:  0.801476705
p_ni:  0.198523295
Score:  0.21
Data Source:  BioPlex,STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.93
Data Source:  STRINGDB
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
Score:  0.923
Data Source:  STRINGDB
IDUA
Tbio
Family:  Enzyme
Novelty:  0.00288117
Score:  0.923
Data Source:  STRINGDB
IDS
Tbio
Family:  Enzyme
Novelty:  0.00733996
Score:  0.911
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
CS/DS degradation (R-HSA-2024101)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
CS/DS degradation
Chondroitin sulfate/dermatan sulfate metabolism
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
7
14
99.5
reticulocyte count
2
4
8
98.7
mean reticulocyte volume
1
1
1
85.1
chronotype measurement
1
2
0
1
78.7
macrophage inflammatory protein 1b measurement
1
2
2
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
14
99.5
reticulocyte count
8
98.7
mean reticulocyte volume
1
85.1
chronotype measurement
0
1
78.7
macrophage inflammatory protein 1b measurement
2
66.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyaluronoglucosaminidase 1
VGNC:1839
460390
Mouse
MGI:96298
15586
Rat
RGD:1303060
367166
Dog
hyaluronoglucosaminidase 1
VGNC:54314
608602
Horse
hyaluronidase-2
100061845
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyaluronoglucosaminidase 1
Mouse
Rat
Dog
hyaluronoglucosaminidase 1
Horse
hyaluronidase-2
Publication Statistics
PubMed Score 137.62
PubMed score by year
PubTator Score 98.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title