HVCN1
Voltage-gated hydrogen channel 1
Protein Summary
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- ENST00000242607
- ENSP00000242607
- ENSG00000122986
- ENST00000356742
- ENSP00000349181
- ENST00000439744
- ENSP00000412052
- ENST00000548312
- ENSP00000449601
- ENST00000620084
- ENSP00000479812
- VSOP
- HV1
- VSOP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.67 | ||
transcription factor | 0.64 | ||
molecular function | 0.63 | ||
cell line | 0.52 | ||
cellular component | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 582.42 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 145 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 582.42 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 145 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (115)
OXLD1
Family: Enzyme
Novelty: 23
p_int: 0.995240104
p_ni: 0.00072452
p_wrong: 0.004035377
Data Source: BioPlex
CST1
Novelty: 0.02399609
p_int: 0.992922824
p_ni: 0.001618629
p_wrong: 0.005458547
Score: 0.211
Data Source: BioPlex,STRINGDB
DOK2
Novelty: 0.02651438
p_int: 0.967830553
p_ni: 0.026011133
p_wrong: 0.006158314
Score: 0.3
Data Source: BioPlex,STRINGDB
JCHAIN
Novelty: 0.00172454
p_int: 0.966964281
p_ni: 0.005394156
p_wrong: 0.027641563
Score: 0.159
Data Source: BioPlex,STRINGDB
PIGR
Novelty: 0.0025812
p_int: 0.923897325
p_ni: 0.013652692
p_wrong: 0.062449983
Score: 0.21
Data Source: BioPlex,STRINGDB
MUCL1
Novelty: 0.05915667
p_int: 0.87123605
p_ni: 0.128761793
p_wrong: 0.000002156
Score: 0.228
Data Source: BioPlex,STRINGDB
CDK2AP1
Family: Enzyme
Novelty: 0.01584718
p_int: 0.849795098
p_ni: 0.001017285
p_wrong: 0.149187617
Data Source: BioPlex
Nearest Tclin Targets
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fertilization | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Reactome | ROS and RNS production in phagocytes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fertilization | ||||
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
ROS and RNS production in phagocytes | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (5)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hydrogen voltage gated channel 1 | VGNC:13147 | 737161 | |||||
Macaque | hydrogen voltage gated channel 1 | 709745 | ||||||
Mouse | MGI:1921346 | 74096 | ||||||
Rat | RGD:1310788 | 304485 | ||||||
Dog | hydrogen voltage gated channel 1 | VGNC:41842 | 608547 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hydrogen voltage gated channel 1 | |||||
Macaque | hydrogen voltage gated channel 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hydrogen voltage gated channel 1 | |||||
Publication Statistics
PubMed Score 582.42
PubMed score by year
PubTator Score 249.53
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (46)
GeneRif Annotations (37)
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