Protein Summary
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]
- ENST00000380907
- ENSP00000370293
- ENSG00000188996
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.81 | ||
cell type or tissue | 0.56 | ||
cellular component | 0.53 | ||
biological process | 0.51 | ||
cell line | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.59 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 104 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.59 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 104 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
RAD1
Novelty: 0.0060275
p_int: 0.999999972
p_ni: 2.7e-8
p_wrong: 1e-9
Score: 0.99
Data Source: BioPlex,STRINGDB
RAD9A
Novelty: 0.00560195
p_int: 0.999999672
p_ni: 6.9e-8
p_wrong: 2.59e-7
Score: 0.989
Data Source: BioPlex,STRINGDB
ZBTB14
Family: TF
Novelty: 0.0245914
p_int: 0.999999615
p_ni: 4.7e-8
p_wrong: 3.38e-7
Score: 0.859
Data Source: BioPlex,STRINGDB
DNLZ
Novelty: 0.10113346
p_int: 0.967451732
p_ni: 0.032509437
p_wrong: 0.000038831
Score: 0.169
Data Source: BioPlex,STRINGDB
FAM192A
Novelty: 0.46220707
p_int: 0.90517795
p_ni: 0.09482205
Score: 0.609
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
WikiPathways (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | DNA Damage Response | ||||
WikiPathways | miRNA Regulation of DNA Damage Response | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA Damage Response | ||||
miRNA Regulation of DNA Damage Response | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 3 | 5 | 96.2 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 3 | 81.1 | |||||
intraocular pressure measurement | 4 | 2 | 5 | 76.7 | |||||
2 | 2 | 0 | 1.2 | 76.2 | |||||
sum of eosinophil and basophil counts | 1 | 1 | 1 | 71.3 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 5 | 96.2 | |||||
eosinophil percentage of leukocytes | 3 | 81.1 | |||||
intraocular pressure measurement | 5 | 76.7 | |||||
0 | 1.2 | 76.2 | |||||
sum of eosinophil and basophil counts | 1 | 71.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | HUS1 checkpoint clamp component B | 706408 | ||||||
Mouse | MGI:2671003 | 210554 | ||||||
Rat | RGD:1585035 | 691382 | ||||||
C. elegans | 171939 | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | HUS1 checkpoint clamp component B | |||||
Mouse | ||||||
Rat | ||||||
C. elegans | ||||||
Publication Statistics
PubMed Score 2.59
PubMed score by year
PubTator Score 2.25
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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