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Tdark
HUS1B
Checkpoint protein HUS1B

Protein Summary
Description
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380907
  • ENSP00000370293
  • ENSG00000188996
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.81
cell type or tissue
0.56
cellular component
0.53
biological process
0.51
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
RAD1
Tchem
Novelty:  0.0060275
p_int:  0.999999972
p_ni:  2.7e-8
p_wrong:  1e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
RAD9A
Tbio
Novelty:  0.00560195
p_int:  0.999999672
p_ni:  6.9e-8
p_wrong:  2.59e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
ZBTB14
Tbio
Family:  TF
Novelty:  0.0245914
p_int:  0.999999615
p_ni:  4.7e-8
p_wrong:  3.38e-7
Score:  0.859
Data Source:  BioPlex,STRINGDB
DNLZ
Tdark
Novelty:  0.10113346
p_int:  0.967451732
p_ni:  0.032509437
p_wrong:  0.000038831
Score:  0.169
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.954127834
p_ni:  0.045872166
Data Source:  BioPlex
FAM192A
Tdark
Novelty:  0.46220707
p_int:  0.90517795
p_ni:  0.09482205
Score:  0.609
Data Source:  BioPlex,STRINGDB
PCDH7
Tbio
Novelty:  0.04017185
p_int:  0.857804283
p_ni:  0.142195717
Data Source:  BioPlex
RAD9B
Tdark
Novelty:  0.38973762
Score:  0.983
Data Source:  STRINGDB
RAD17
Tbio
Novelty:  0.00640979
Score:  0.817
Data Source:  STRINGDB
HUS1
Tbio
Novelty:  0.00837493
Score:  0.675
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
5
96.2
eosinophil percentage of leukocytes
2
2
3
81.1
intraocular pressure measurement
4
2
5
76.7
2
2
0
1.2
76.2
sum of eosinophil and basophil counts
1
1
1
71.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
96.2
eosinophil percentage of leukocytes
3
81.1
intraocular pressure measurement
5
76.7
0
1.2
76.2
sum of eosinophil and basophil counts
1
71.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
HUS1 checkpoint clamp component B
706408
Mouse
MGI:2671003
210554
Rat
RGD:1585035
691382
C. elegans
171939
Species
Name
OMA
EggNOG
Inparanoid
Macaque
HUS1 checkpoint clamp component B
Mouse
Rat
C. elegans
Publication Statistics
PubMed Score 2.59
PubMed score by year
PubTator Score 2.25
PubTator score by year
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Related Publications
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PMID
Year
Title