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Tbio
HUS1
Checkpoint protein HUS1

Protein Summary
Description
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258774
  • ENSP00000258774
  • ENSG00000136273
  • ENST00000432325
  • ENSP00000416588
  • ENST00000458191
  • ENSP00000400727

Symbol
  • hHUS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
disease perturbation
0.83
biological process
0.82
transcription factor binding site profile
0.77
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.89   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.89   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (157)
RAD1
Tchem
Novelty:  0.0060275
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RAD9A
Tbio
Novelty:  0.00560195
p_int:  0.999999713
p_ni:  2.86e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ZBTB14
Tbio
Family:  TF
Novelty:  0.0245914
p_int:  0.999999669
p_ni:  2.8e-7
p_wrong:  5.2e-8
Score:  0.862
Data Source:  BioPlex,STRINGDB
RAD17
Tbio
Novelty:  0.00640979
p_int:  0.999996519
p_ni:  0.00000347
p_wrong:  1.1e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.999909324
p_ni:  0.000090663
p_wrong:  1.3e-8
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.999660557
p_ni:  0.000339316
p_wrong:  1.27e-7
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.995868343
p_ni:  0.004126914
p_wrong:  0.000004744
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.991193859
p_ni:  0.008795509
p_wrong:  0.000010633
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.990673842
p_ni:  0.009320464
p_wrong:  0.000005693
Data Source:  BioPlex
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.967591337
p_ni:  0.00683446
p_wrong:  0.025574203
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
4.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HUS1 checkpoint clamp component
VGNC:14025
463402
Macaque
HUS1 checkpoint clamp component
699541
Mouse
MGI:1277962
15574
Rat
RGD:1591976
498411
Dog
HUS1 checkpoint clamp component
VGNC:41840
606789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HUS1 checkpoint clamp component
Macaque
HUS1 checkpoint clamp component
Mouse
Rat
Dog
HUS1 checkpoint clamp component
Publication Statistics
PubMed Score 104.89
PubMed score by year
PubTator Score 35.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title