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Tbio
HTRA4
Serine protease HTRA4

Protein Summary
Description
Serine protease. This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302495
  • ENSP00000305919
  • ENSG00000169495
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
protein domain
0.85
PubMedID
0.49
tissue sample
0.49
cell line
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.34   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.34   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
OTUD4
Tbio
Novelty:  0.17121119
p_int:  0.999993927
p_ni:  0.000006073
Score:  0.198
Data Source:  BioPlex,STRINGDB
TTC28
Tdark
Novelty:  0.16651519
p_int:  0.99996538
p_ni:  0.000034614
p_wrong:  6e-9
Score:  0.202
Data Source:  BioPlex,STRINGDB
ZC3H4
Tbio
Novelty:  0.14897433
p_int:  0.997230503
p_ni:  0.002618482
p_wrong:  0.000151015
Score:  0.255
Data Source:  BioPlex,STRINGDB
CPSF4
Tbio
Novelty:  0.00206207
p_int:  0.990848328
p_ni:  0.009084847
p_wrong:  0.000066825
Score:  0.193
Data Source:  BioPlex,STRINGDB
RBPMS
Tbio
Novelty:  0.01727259
p_int:  0.9874525
p_ni:  0.011844784
p_wrong:  0.000702716
Score:  0.199
Data Source:  BioPlex,STRINGDB
WDCP
Tdark
Novelty:  0.29184907
p_int:  0.984143564
p_ni:  0.015856436
Score:  0.169
Data Source:  BioPlex,STRINGDB
RBMS1
Tbio
Novelty:  0.00520684
p_int:  0.900375407
p_ni:  0.098553875
p_wrong:  0.001070718
Score:  0.189
Data Source:  BioPlex,STRINGDB
WDR26
Tbio
Novelty:  0.04140166
p_int:  0.812522682
p_ni:  0.187477318
Score:  0.173
Data Source:  BioPlex,STRINGDB
EIF4E2
Tbio
Novelty:  0.0490219
p_int:  0.812233618
p_ni:  0.187766381
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
TM4SF19
Tdark
Novelty:  0.51361063
Score:  0.73
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
47.7
monocyte count
1
1
1
40.7
basophil count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
47.7
monocyte count
1
40.7
basophil count
1
35
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HtrA serine peptidase 4
VGNC:863
472743
Macaque
HtrA serine peptidase 4
700875
Mouse
MGI:3036260
330723
Rat
RGD:1306242
306564
Dog
HtrA serine peptidase 4
VGNC:41838
475580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HtrA serine peptidase 4
Macaque
HtrA serine peptidase 4
Mouse
Rat
Dog
HtrA serine peptidase 4
Publication Statistics
PubMed Score 15.34
PubMed score by year
PubTator Score 7.03
PubTator score by year
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Related Publications
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PMID
Year
Title