Tchem HTRA1 Serine protease HTRA1

Protein Summary

Description

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92743
• D3DRE4
• Q9UNS5

Gene Name

• HTRA1

Ensembl ID

• ENST00000368984
• ENSP00000357980
• ENSG00000166033

Symbol

• HTRA
• PRSS11
• L56
• HtrA
• ARMD7
• ORF480
• PRSS11
• CARASIL
• CADASIL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
PubMedID	0.99
transcription factor perturbation	0.94
biological term	0.92
gene perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Serine Protease Htra1

Protein / Chaperone / Serine Protease Htra1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Serine Protease Htra1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 734.66   (req: < 5)

Gene RIFs: 279   (req: <= 3)

Antibodies: 260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 734.66   (req: >= 5)

Gene RIFs: 279   (req: > 3)

Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 184

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0