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Tchem
HTRA1
Serine protease HTRA1

Protein Summary
Description
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. This ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368984
  • ENSP00000357980
  • ENSG00000166033

Symbol
  • HTRA
  • PRSS11
  • L56
  • HtrA
  • ARMD7
  • ORF480
  • PRSS11
  • CARASIL
  • CADASIL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
PubMedID
0.99
transcription factor perturbation
0.94
biological term
0.92
gene perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 645.68   (req: < 5)
Gene RIFs: 203   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 645.68   (req: >= 5)
Gene RIFs: 203   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 184
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (184)
CHEMBL4589967
Rendered image for CHEMBL4589967
CHEMBL4554156
Rendered image for CHEMBL4554156
CHEMBL4542635
Rendered image for CHEMBL4542635
CHEMBL4471645
Rendered image for CHEMBL4471645
CHEMBL4533165
Rendered image for CHEMBL4533165
CHEMBL4471714
Rendered image for CHEMBL4471714
CHEMBL4540590
Rendered image for CHEMBL4540590
CHEMBL4461666
Rendered image for CHEMBL4461666
CHEMBL4585025
Rendered image for CHEMBL4585025
CHEMBL4588306
Rendered image for CHEMBL4588306
Protein-Protein Interactions (95)
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.999947389
p_ni:  0.000052256
p_wrong:  3.56e-7
Data Source:  BioPlex
SPINK4
Tdark
Family:  Enzyme
Novelty:  0.06706505
p_int:  0.999923967
p_ni:  0.00005544
p_wrong:  0.000020593
Score:  0.188
Data Source:  BioPlex,STRINGDB
REG4
Tbio
Novelty:  0.01123311
p_int:  0.999918533
p_ni:  0.00004259
p_wrong:  0.000038877
Score:  0.187
Data Source:  BioPlex,STRINGDB
AVP
Tbio
Novelty:  0.00016475
p_int:  0.99977256
p_ni:  0.000227369
p_wrong:  7.1e-8
Score:  0.197
Data Source:  BioPlex,STRINGDB
DEFB127
Tbio
Novelty:  0.18126756
p_int:  0.999498869
p_ni:  0.000501109
p_wrong:  2.2e-8
Score:  0.157
Data Source:  BioPlex,STRINGDB
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.999183131
p_ni:  0.000780333
p_wrong:  0.000036536
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.998882072
p_ni:  0.000533497
p_wrong:  0.000584431
Data Source:  BioPlex
NOG
Tbio
Novelty:  0.0010373
p_int:  0.998611655
p_ni:  0.000669766
p_wrong:  0.000718579
Data Source:  BioPlex
C12orf49
Tdark
Novelty:  0.56030929
p_int:  0.998195652
p_ni:  0.001650952
p_wrong:  0.000153397
Score:  0.173
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.995929102
p_ni:  0.003926221
p_wrong:  0.000144677
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Degradation of the extracellular matrix (R-HSA-1474228)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
15
9
1
2.2
99.8
5
3
0
2.3
98.2
atrophic macular degeneration
3
2
0
2.5
96.2
8
5
4
1.1
90.8
disease progression measurement
1
1
0
2.1
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2.2
99.8
0
2.3
98.2
atrophic macular degeneration
0
2.5
96.2
4
1.1
90.8
disease progression measurement
0
2.1
83
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HtrA serine peptidase 1
VGNC:7229
450792
Macaque
HtrA serine peptidase 1
705855
Mouse
MGI:1929076
56213
Rat
RGD:69235
65164
Dog
HtrA serine peptidase 1
VGNC:41835
477852
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HtrA serine peptidase 1
Macaque
HtrA serine peptidase 1
Mouse
Rat
Dog
HtrA serine peptidase 1
Publication Statistics
PubMed Score 645.68
PubMed score by year
PubTator Score 327.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title