Protein Summary
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. This ...more
- ENST00000368984
- ENSP00000357980
- ENSG00000166033
- HTRA
- PRSS11
- L56
- HtrA
- ARMD7
- ORF480
- PRSS11
- CARASIL
- CADASIL2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
PubMedID | 0.99 | ||
transcription factor perturbation | 0.94 | ||
biological term | 0.92 | ||
gene perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 645.68 (req: < 5)
Gene RIFs: 203 (req: <= 3)
Antibodies: 260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 645.68 (req: >= 5)
Gene RIFs: 203 (req: > 3)
Antibodies: 260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 184
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (184)
Protein-Protein Interactions (95)
TMEM25
Novelty: 0.35505784
p_int: 0.999947389
p_ni: 0.000052256
p_wrong: 3.56e-7
Data Source: BioPlex
SPINK4
Family: Enzyme
Novelty: 0.06706505
p_int: 0.999923967
p_ni: 0.00005544
p_wrong: 0.000020593
Score: 0.188
Data Source: BioPlex,STRINGDB
REG4
Novelty: 0.01123311
p_int: 0.999918533
p_ni: 0.00004259
p_wrong: 0.000038877
Score: 0.187
Data Source: BioPlex,STRINGDB
AVP
Novelty: 0.00016475
p_int: 0.99977256
p_ni: 0.000227369
p_wrong: 7.1e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
DEFB127
Novelty: 0.18126756
p_int: 0.999498869
p_ni: 0.000501109
p_wrong: 2.2e-8
Score: 0.157
Data Source: BioPlex,STRINGDB
MGAT4C
Family: Enzyme
Novelty: 0.19680806
p_int: 0.999183131
p_ni: 0.000780333
p_wrong: 0.000036536
Data Source: BioPlex
MSMB
Novelty: 0.00241546
p_int: 0.998882072
p_ni: 0.000533497
p_wrong: 0.000584431
Data Source: BioPlex
NOG
Novelty: 0.0010373
p_int: 0.998611655
p_ni: 0.000669766
p_wrong: 0.000718579
Data Source: BioPlex
C12orf49
Novelty: 0.56030929
p_int: 0.998195652
p_ni: 0.001650952
p_wrong: 0.000153397
Score: 0.173
Data Source: BioPlex,STRINGDB
DEFA5
Novelty: 0.00863727
p_int: 0.995929102
p_ni: 0.003926221
p_wrong: 0.000144677
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (4)
Components (6)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
15 | 9 | 1 | 2.2 | 99.8 | |||||
5 | 3 | 0 | 2.3 | 98.2 | |||||
atrophic macular degeneration | 3 | 2 | 0 | 2.5 | 96.2 | ||||
8 | 5 | 4 | 1.1 | 90.8 | |||||
disease progression measurement | 1 | 1 | 0 | 2.1 | 83 | ||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
1 | 2.2 | 99.8 | |||||
0 | 2.3 | 98.2 | |||||
atrophic macular degeneration | 0 | 2.5 | 96.2 | ||||
4 | 1.1 | 90.8 | |||||
disease progression measurement | 0 | 2.1 | 83 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | HtrA serine peptidase 1 | VGNC:7229 | 450792 | |||||
Macaque | HtrA serine peptidase 1 | 705855 | ||||||
Mouse | MGI:1929076 | 56213 | ||||||
Rat | RGD:69235 | 65164 | ||||||
Dog | HtrA serine peptidase 1 | VGNC:41835 | 477852 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | HtrA serine peptidase 1 | |||||
Macaque | HtrA serine peptidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | HtrA serine peptidase 1 | |||||
Publication Statistics
PubMed Score 645.68
PubMed score by year
PubTator Score 327.15
PubTator score by year
Related Publications
Text Mined References (246)
GeneRif Annotations (203)
Items per page:
0 of 0
PMID | Year | Title |
---|