You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
HTR7
5-hydroxytryptamine receptor 7

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277874
  • ENSP00000277874
  • ENSG00000148680
  • ENST00000336152
  • ENSP00000337949
  • ENST00000371719
  • ENSP00000360784

Symbol
  • 5-HT7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
ligand (chemical)
1
drug
0.89
disease perturbation
0.83
histone modification site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 576.11   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 385   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 576.11   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1252
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 32
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (32)
clozapine
Rendered image for clozapine
chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
amitriptyline
Rendered image for amitriptyline
thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
cyproheptadine
Rendered image for cyproheptadine
fluphenazine
Rendered image for fluphenazine
metergoline
Rendered image for metergoline
Protein-Protein Interactions (226)
POMC
Tbio
Novelty:  0.00002436
Score:  0.964
Data Source:  STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.964
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.964
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.962
Data Source:  STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.957
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.957
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.945
Data Source:  STRINGDB
CRHR1
Tclin
Family:  GPCR
Novelty:  0.00101773
Score:  0.941
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.94
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left atrial function
1
1
1
4.4
intraocular pressure measurement
1
1
1
3.7
electrocardiography
1
1
3
3.4
heart function measurement
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left atrial function
1
4.4
intraocular pressure measurement
1
3.7
electrocardiography
3
3.4
heart function measurement
1
0.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 7
VGNC:9746
466154
Mouse
MGI:99841
15566
Rat
RGD:71034
65032
Dog
5-hydroxytryptamine receptor 7
VGNC:41834
477762
Horse
5-hydroxytryptamine receptor 7
VGNC:51542
100009688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 7
Mouse
Rat
Dog
5-hydroxytryptamine receptor 7
Horse
5-hydroxytryptamine receptor 7
Publication Statistics
PubMed Score 576.11
PubMed score by year
PubTator Score 28.21
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title