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Tchem
HTR6
5-hydroxytryptamine receptor 6

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289753
  • ENSP00000289753
  • ENSG00000158748

Symbol
  • 5-HT6
  • 5-HT6R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
drug
0.81
biological process
0.78
phenotype
0.58
disease
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.54   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.54   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2324
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 37
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (37)
clozapine
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chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
amitriptyline
Rendered image for amitriptyline
thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
clemastine
Rendered image for clemastine
cyproheptadine
Rendered image for cyproheptadine
fluphenazine
Rendered image for fluphenazine
Protein-Protein Interactions (131)
ADCY3
Tbio
Family:  Enzyme
Novelty:  0.00260265
Score:  0.94
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.939
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.939
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.939
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.939
Data Source:  STRINGDB
HTR4
Tclin
Family:  GPCR
Novelty:  0.00951779
Score:  0.923
Data Source:  STRINGDB
ADCY7
Tbio
Family:  Enzyme
Novelty:  0.00984562
Score:  0.922
Data Source:  STRINGDB
ADCY4
Tbio
Family:  Enzyme
Novelty:  0.00465974
Score:  0.922
Data Source:  STRINGDB
GIPR
Tchem
Family:  GPCR
Novelty:  0.00961809
Score:  0.92
Data Source:  STRINGDB
HTR7
Tclin
Family:  GPCR
Novelty:  0.00169884
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
1
1
75.7
lymphocyte count
2
2
2
69.1
waist-hip ratio
1
1
1
44.2
body mass index
1
1
1
42.3
myeloid white cell count
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
75.7
lymphocyte count
2
69.1
waist-hip ratio
1
44.2
body mass index
1
42.3
myeloid white cell count
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 6
VGNC:8052
469199
Mouse
MGI:1196627
15565
Rat
RGD:62044
64354
Dog
5-hydroxytryptamine receptor 6
VGNC:41833
487402
Horse
5-hydroxytryptamine receptor 6
VGNC:18909
100058656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 6
Mouse
Rat
Dog
5-hydroxytryptamine receptor 6
Horse
5-hydroxytryptamine receptor 6
Publication Statistics
PubMed Score 92.54
PubMed score by year
PubTator Score 89.78
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title