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Tclin
HTR3A
5-hydroxytryptamine receptor 3A

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms ha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299961
  • ENSP00000299961
  • ENSG00000166736
  • ENST00000355556
  • ENSP00000347754
  • ENST00000375498
  • ENSP00000364648
  • ENST00000504030
  • ENSP00000424189
  • ENST00000506841
  • ENSP00000424776

Symbol
  • 5HT3R
  • HTR3
  • HTR3
  • 5HT3R
  • 5-HT-3
  • 5-HT3A
  • 5-HT3R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
drug
0.92
protein domain
0.92
disease
0.87
phenotype
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.62   (req: < 5)
Gene RIFs: 96   (req: <= 3)
Antibodies: 379   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.62   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 718
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (20)
clozapine
Rendered image for clozapine
olanzapine
Rendered image for olanzapine
aripiprazole
Rendered image for aripiprazole
cisapride
Rendered image for cisapride
mirtazapine
Rendered image for mirtazapine
diltiazem
Rendered image for diltiazem
metoclopramide
Rendered image for metoclopramide
tropisetron
Rendered image for tropisetron
vortioxetine
Rendered image for vortioxetine
sumatriptan
Rendered image for sumatriptan
Protein-Protein Interactions (245)
OCA2
Tbio
Novelty:  0.00249611
p_int:  0.999998577
p_ni:  0.00000123
p_wrong:  1.93e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
HLA-DOA
Tbio
Novelty:  0.01222732
p_int:  0.999998446
p_ni:  0.000001394
p_wrong:  1.6e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
ABCA7
Tbio
Family:  Transporter
Novelty:  0.00808369
p_int:  0.999994347
p_ni:  0.000005586
p_wrong:  6.7e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
UGT3A2
Tbio
Family:  Enzyme
Novelty:  0.35904542
p_int:  0.999981771
p_ni:  0.000018096
p_wrong:  1.33e-7
Score:  0.153
Data Source:  BioPlex,STRINGDB
LRRC8D
Tbio
Novelty:  0.10536285
p_int:  0.999977424
p_ni:  0.000022561
p_wrong:  1.5e-8
Data Source:  BioPlex
SLC41A3
Tdark
Family:  Transporter
Novelty:  0.20246441
p_int:  0.999932622
p_ni:  0.000026952
p_wrong:  0.000040426
Data Source:  BioPlex
PANX1
Tbio
Family:  IC
Novelty:  0.00159814
p_int:  0.999928551
p_ni:  0.000059599
p_wrong:  0.00001185
Score:  0.241
Data Source:  BioPlex,STRINGDB
PLPPR3
Tbio
Family:  Enzyme
Novelty:  0.03836833
p_int:  0.999909391
p_ni:  0.000049315
p_wrong:  0.000041294
Data Source:  BioPlex
MARCH6
Tbio
Family:  Enzyme
Novelty:  0.01818691
p_int:  0.999786532
p_ni:  0.000184249
p_wrong:  0.000029219
Data Source:  BioPlex
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.99974142
p_ni:  0.000258297
p_wrong:  2.84e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
93
neutrophil count
2
2
2
91.5
leukocyte count
2
2
2
89.7
mean platelet volume
3
1
3
86.4
platelet count
2
1
2
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
93
neutrophil count
2
91.5
leukocyte count
2
89.7
mean platelet volume
3
86.4
platelet count
2
84.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 3A
VGNC:7649
451556
Macaque
5-hydroxytryptamine receptor 3A
696912
Mouse
MGI:96282
15561
Rat
RGD:61818
79246
Dog
5-hydroxytryptamine receptor 3A
VGNC:41829
489399
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 3A
Macaque
5-hydroxytryptamine receptor 3A
Mouse
Rat
Dog
5-hydroxytryptamine receptor 3A
Publication Statistics
PubMed Score 509.62
PubMed score by year
PubTator Score 285.19
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title