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Tclin
HTR2A
5-hydroxytryptamine receptor 2A

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378688
  • ENSP00000367959
  • ENSG00000102468
  • ENST00000542664
  • ENSP00000437737
  • ENST00000543956
  • ENSP00000441861

Symbol
  • HTR2
  • HTR2
  • 5-HT2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug
1
ligand (chemical)
1
chemical
0.9
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2837.36   (req: < 5)
Gene RIFs: 430   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2837.36   (req: >= 5)
Gene RIFs: 430   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2448
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 82
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (82)
clozapine
Rendered image for clozapine
chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
amitriptyline
Rendered image for amitriptyline
thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
clemastine
Rendered image for clemastine
cyproheptadine
Rendered image for cyproheptadine
fluphenazine
Rendered image for fluphenazine
Protein-Protein Interactions (256)
GRM5
Tchem
Family:  GPCR
Novelty:  0.00062552
Score:  0.964
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.958
Data Source:  STRINGDB
GRM1
Tchem
Family:  GPCR
Novelty:  0.00099764
Score:  0.953
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.952
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.95
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.948
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.947
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.947
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.946
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (56)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
1
0
5.9
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
0
5.9
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 2A
VGNC:9791
467355
Macaque
5-hydroxytryptamine receptor 2A
613032
Mouse
MGI:109521
15558
Rat
RGD:61800
29595
Horse
5-hydroxytryptamine receptor 2A
VGNC:18903
100009685
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 2A
Macaque
5-hydroxytryptamine receptor 2A
Mouse
Rat
Horse
5-hydroxytryptamine receptor 2A
Publication Statistics
PubMed Score 2837.36
PubMed score by year
PubTator Score 2180.61
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title