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Tclin
HTR1D
5-hydroxytryptamine receptor 1D

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374619
  • ENSP00000363748
  • ENSG00000179546

Symbol
  • HTR1DA
  • HTRL
  • HTRL
  • RDC4
  • HT1DA
  • 5-HT1D
  • HTR1DA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
drug
0.96
disease perturbation
0.79
gene perturbation
0.72
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.42   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.42   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 853
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 27