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Tclin
HTR1A
5-hydroxytryptamine receptor 1A

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. This gene encodes a G prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323865
  • ENSP00000316244
  • ENSG00000178394

Symbol
  • ADRB2RL1
  • ADRBRL1
  • G-21
  • 5HT1a
  • PFMCD
  • 5-HT1A
  • 5-HT-1A
  • ADRBRL1
  • ADRB2RL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
disease
0.95
chemical
0.92
protein complex
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6475.97   (req: < 5)
Gene RIFs: 264   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6475.97   (req: >= 5)
Gene RIFs: 264   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2939
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 46
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (46)
clozapine
Rendered image for clozapine
chlorpromazine
Rendered image for chlorpromazine
thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
lisuride
Rendered image for lisuride
metergoline
Rendered image for metergoline
ziprasidone
Rendered image for ziprasidone
quetiapine
Rendered image for quetiapine
ketanserin
Rendered image for ketanserin
Protein-Protein Interactions (344)
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.964
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.964
Data Source:  STRINGDB
SLC6A4
Tclin
Family:  Transporter
Novelty:  0.00017603
Score:  0.962
Data Source:  STRINGDB
GRM2
Tchem
Family:  GPCR
Novelty:  0.00132156
Score:  0.96
Data Source:  STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.959
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.957
Data Source:  STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.952
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.952
Data Source:  STRINGDB
ADCY1
Tchem
Family:  Enzyme
Novelty:  0.01089602
Score:  0.95
Data Source:  STRINGDB
GPR55
Tclin
Family:  GPCR
Novelty:  0.00428199
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Amine ligand-binding receptors (R-HSA-375280)

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Find Similar Targets
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1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 1A
VGNC:8624
471533
Macaque
5-hydroxytryptamine receptor 1A
694991
Mouse
MGI:96273
15550
Rat
RGD:2845
24473
Dog
5-hydroxytryptamine receptor 1A
VGNC:41823
487230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 1A
Macaque
5-hydroxytryptamine receptor 1A
Mouse
Rat
Dog
5-hydroxytryptamine receptor 1A
Publication Statistics
PubMed Score 6475.97
PubMed score by year
PubTator Score 2138.32
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title