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Tclin
HTR1A
5-hydroxytryptamine receptor 1A

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. This gene encodes a G prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323865
  • ENSP00000316244
  • ENSG00000178394

Symbol
  • ADRB2RL1
  • ADRBRL1
  • G-21
  • 5HT1a
  • PFMCD
  • 5-HT1A
  • 5-HT-1A
  • ADRBRL1
  • ADRB2RL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
disease
0.95
chemical
0.92
protein complex
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7223.31   (req: < 5)
Gene RIFs: 264   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7223.31   (req: >= 5)
Gene RIFs: 264   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3125
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 46