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Tbio
HTN1
Histatin-1

Protein Summary
Description
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246896
  • ENSP00000246896
  • ENSG00000126550
  • ENST00000511674
  • ENSP00000424501
  • ENST00000610341
  • ENSP00000482787
  • ENST00000634477
  • ENSP00000489510
  • ENSG00000283046
  • ENST00000635327
  • ENSP00000489349
  • ENST00000635569
  • ENSP00000489198

Symbol
  • HIS1
  • HIS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.49
gene perturbation
0.46
cell type or tissue
0.41
transcription factor
0.34
biological term
0.32


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.38   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.38   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (13)
STATH
Tbio
Novelty:  0.00486778
Score:  0.905
Data Source:  STRINGDB
HTN3
Tbio
Novelty:  0.00825966
Score:  0.903
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.696
Data Source:  STRINGDB
CST4
Tbio
Novelty:  0.00773554
Score:  0.651
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.575
Data Source:  STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
Score:  0.527
Data Source:  STRINGDB
PRH1
Tbio
Novelty:  0.00270573
Score:  0.513
Data Source:  STRINGDB
CST1
Tbio
Novelty:  0.02399609
Score:  0.491
Data Source:  STRINGDB
PRR27
Tdark
Novelty:  2.26243094
Score:  0.489
Data Source:  STRINGDB
UCN
Tbio
Novelty:  0.00151712
Score:  0.469
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histatin 1
VGNC:615
741226
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histatin 1
Publication Statistics
PubMed Score 133.38
PubMed score by year
PubTator Score 115.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title