HSPG2
Basement membrane-specific heparan sulfate proteoglycan core protein
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
cellular component | 0.92 | ||
biological term | 0.78 | ||
transcription factor | 0.74 | ||
interacting protein | 0.73 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Reactome | Defective B3GAT3 causes JDSSDHD | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Amyloid fiber formation | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Defective B3GAT3 causes JDSSDHD | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 1 | 1 | 1 | 69.5 | |||||
testosterone measurement | 1 | 1 | 1 | 65.3 | |||||
myeloid white cell count | 1 | 1 | 1 | 64.4 | |||||
leukocyte count | 1 | 1 | 1 | 55.2 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 40.7 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 1 | 69.5 | |||||
testosterone measurement | 1 | 65.3 | |||||
myeloid white cell count | 1 | 64.4 | |||||
leukocyte count | 1 | 55.2 | |||||
BMI-adjusted hip circumference | 1 | 40.7 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | heparan sulfate proteoglycan 2 | VGNC:52978 | 100613114 | |||||
Macaque | heparan sulfate proteoglycan 2 | 707213 | ||||||
Mouse | MGI:96257 | 15530 | ||||||
Dog | heparan sulfate proteoglycan 2 | VGNC:41820 | 403440 | |||||
Horse | heparan sulfate proteoglycan 2 | VGNC:18898 | 100071701 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | heparan sulfate proteoglycan 2 | |||||
Macaque | heparan sulfate proteoglycan 2 | |||||
Mouse | ||||||
Dog | heparan sulfate proteoglycan 2 | |||||
Horse | heparan sulfate proteoglycan 2 | |||||
PMID | Year | Title |
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