You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HSPBP1
Hsp70-binding protein 1

Protein Summary
Description
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255631
  • ENSP00000255631
  • ENSG00000133265
  • ENST00000433386
  • ENSP00000398244
  • ENST00000587922
  • ENSP00000467574

Symbol
  • HSPBP
  • FES1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
histone modification site profile
0.79
interacting protein
0.72
tissue
0.72
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.42   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.42   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (337)
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
p_int:  0.999999979
p_ni:  1e-8
p_wrong:  1.1e-8
Score:  0.382
Data Source:  BioPlex,STRINGDB
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.999999778
p_ni:  2.21e-7
p_wrong:  1e-9
Score:  0.39
Data Source:  BioPlex,STRINGDB
ELF1
Tbio
Family:  TF
Novelty:  0.10888716
p_int:  0.999999203
p_ni:  7.97e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
ARMC1
Tbio
Novelty:  0.02018109
p_int:  0.99999433
p_ni:  0.00000567
Data Source:  BioPlex
ELF2
Tbio
Family:  TF
Novelty:  0.01302604
p_int:  0.999994059
p_ni:  0.000005937
p_wrong:  4e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
HSF1
Tchem
Family:  TF
Novelty:  0.00450276
p_int:  0.999993563
p_ni:  0.000006436
p_wrong:  1e-9
Score:  0.683
Data Source:  BioPlex,STRINGDB
C6orf106
Tbio
Novelty:  0.31629241
p_int:  0.999987389
p_ni:  2.86e-7
p_wrong:  0.000012325
Score:  0.734
Data Source:  BioPlex,STRINGDB
ABL2
Tchem
Family:  Kinase
Novelty:  0.00952983
p_int:  0.999951777
p_ni:  0.000013179
p_wrong:  0.000035045
Score:  0.396
Data Source:  BioPlex,STRINGDB
CCDC117
Tdark
Novelty:  1.11966553
p_int:  0.999833533
p_ni:  0.000166467
Score:  0.313
Data Source:  BioPlex,STRINGDB
CLTCL1
Tbio
Novelty:  0.05667807
p_int:  0.99983254
p_ni:  0.00016746
Score:  0.197
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
4
2
4
94.7
platelet crit
2
4
5
90.3
mean corpuscular volume
1
3
3
87.5
platelet count
3
4
4
86.9
appendicular lean mass
3
1
3
81.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
4
94.7
platelet crit
5
90.3
mean corpuscular volume
3
87.5
platelet count
4
86.9
appendicular lean mass
3
81.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HSPA (Hsp70) binding protein 1
VGNC:13184
456299
Macaque
HSPA (Hsp70) binding protein 1 [Source:HGNC Symbol;Acc:HGNC:24989]
Mouse
MGI:1913495
66245
Rat
RGD:628677
246146
Dog
HSPA (Hsp70) binding protein 1
VGNC:53527
476381
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HSPA (Hsp70) binding protein 1
Macaque
HSPA (Hsp70) binding protein 1 [Source:HGNC Symbol;Acc:HGNC:24989]
Mouse
Rat
Dog
HSPA (Hsp70) binding protein 1
Publication Statistics
PubMed Score 64.42
PubMed score by year
PubTator Score 42.13
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title