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Tbio
HSPBP1
Hsp70-binding protein 1

Protein Summary
Description
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255631
  • ENSP00000255631
  • ENSG00000133265
  • ENST00000433386
  • ENSP00000398244
  • ENST00000587922
  • ENSP00000467574

Symbol
  • HSPBP
  • FES1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
histone modification site profile
0.79
interacting protein
0.72
tissue
0.72
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.7   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.7   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0