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Tbio
HSPB8
Heat shock protein beta-8

Protein Summary
Description
Displays temperature-dependent chaperone activity. The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281938
  • ENSP00000281938
  • ENSG00000152137

Symbol
  • CRYAC
  • E2IG1
  • HSP22
  • H11
  • HMN2
  • CMT2L
  • DHMN2
  • E2IG1
  • HMN2A
  • HSP22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.95
PubMedID
0.95
kinase perturbation
0.84
small molecule perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.34   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 552   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.34   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
p_int:  0.999993841
p_ni:  0.000006159
Score:  0.221
Data Source:  BioPlex,STRINGDB
IRAK3
Tchem
Family:  Kinase
Novelty:  0.01001206
p_int:  0.999885915
p_ni:  0.00002936
p_wrong:  0.000084726
Data Source:  BioPlex
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.998678337
p_ni:  0.001214681
p_wrong:  0.000106981
Score:  0.392
Data Source:  BioPlex,STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
p_int:  0.994084632
p_ni:  0.005915368
Data Source:  BioPlex
FAM83H
Tbio
Novelty:  0.02527211
p_int:  0.993780754
p_ni:  0.006219246
Data Source:  BioPlex
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.99177725
p_ni:  0.00822275
Data Source:  BioPlex
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
p_int:  0.989616618
p_ni:  0.010383382
Score:  0.181
Data Source:  BioPlex,STRINGDB
BAG3
Tbio
Novelty:  0.0042967
p_int:  0.987744442
p_ni:  0.012255558
Score:  0.925
Data Source:  BioPlex,STRINGDB
VWA8
Tdark
Novelty:  0.17546432
p_int:  0.987013261
p_ni:  0.012986739
Score:  0.392
Data Source:  BioPlex,STRINGDB
ZNF92
Tbio
Family:  TF
Novelty:  0.05724663
p_int:  0.942822356
p_ni:  0.056411924
p_wrong:  0.00076572
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cellular response to heat stress (R-HSA-3371556)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1-dependent transactivation
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1-dependent transactivation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family B (small) member 8
VGNC:5424
452295
Macaque
heat shock protein family B (small) member 8
574341
Mouse
MGI:2135756
80888
Rat
RGD:71003
113906
Dog
heat shock protein family B (small) member 8
VGNC:52935
403553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family B (small) member 8
Macaque
heat shock protein family B (small) member 8
Mouse
Rat
Dog
heat shock protein family B (small) member 8
Publication Statistics
PubMed Score 361.34
PubMed score by year
PubTator Score 88.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title