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Tbio
HSPB7
Heat shock protein beta-7

Protein Summary
Description
This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311890
  • ENSP00000310111
  • ENSG00000173641
  • ENST00000487046
  • ENSP00000419477

Symbol
  • CVHSP
  • cvHSP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.61
tissue sample
0.6
gene perturbation
0.51
cell line
0.5
disease
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.92   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.92   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.999935381
p_ni:  0.000064619
Score:  0.728
Data Source:  BioPlex,STRINGDB
FLNA
Tbio
Novelty:  0.00156479
p_int:  0.999476352
p_ni:  0.000523648
Score:  0.949
Data Source:  BioPlex,STRINGDB
FLNB
Tbio
Novelty:  0.00568768
p_int:  0.993285059
p_ni:  0.006714941
Score:  0.579
Data Source:  BioPlex,STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
p_int:  0.985321671
p_ni:  0.014678304
p_wrong:  2.5e-8
Score:  0.315
Data Source:  BioPlex,STRINGDB
HSPB3
Tbio
Novelty:  0.00078884
Score:  0.829
Data Source:  STRINGDB
BAG3
Tbio
Novelty:  0.0042967
Score:  0.79
Data Source:  STRINGDB
HSPB9
Tbio
Novelty:  0.09680405
Score:  0.775
Data Source:  STRINGDB
FRMD4B
Tbio
Novelty:  0.20691438
Score:  0.73
Data Source:  STRINGDB
SMPX
Tbio
Novelty:  0.05084864
Score:  0.714
Data Source:  STRINGDB
MYOZ2
Tbio
Novelty:  0.04557513
Score:  0.711
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Differentiation of white and brown adipocyte
WikiPathways
Differentiation of white and brown adipocyte
WikiPathways
Differentiation of white and brown adipocyte
WikiPathways
Differentiation of white and brown adipocyte
WikiPathways
Differentiation of white and brown adipocyte
Name
Explore in Pharos
Explore in Source
Differentiation of white and brown adipocyte
Differentiation of white and brown adipocyte
Differentiation of white and brown adipocyte
Differentiation of white and brown adipocyte
Differentiation of white and brown adipocyte
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
5
5
96.9
heel bone mineral density
2
2
2
90.4
hematocrit
2
2
2
90
hemoglobin measurement
2
2
2
89.1
3
2
1
1.3
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
96.9
heel bone mineral density
2
90.4
hematocrit
2
90
hemoglobin measurement
2
89.1
1
1.3
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family B (small) member 7
VGNC:6880
740755
Macaque
heat shock protein family B (small) member 7
696704
Mouse
MGI:1352494
29818
Rat
RGD:62021
50565
Dog
heat shock protein family B (small) member 7
VGNC:52138
487423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family B (small) member 7
Macaque
heat shock protein family B (small) member 7
Mouse
Rat
Dog
heat shock protein family B (small) member 7
Publication Statistics
PubMed Score 36.92
PubMed score by year
PubTator Score 16.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title