You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HSPB2
Heat shock protein beta-2

Protein Summary
Description
May regulate the kinase DMPK. The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304298
  • ENSP00000302476
  • ENSG00000170276

Symbol
  • MKBP
  • HSP27
  • Hs.78846
  • LOH11CR1K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
PubMedID
0.79
cell type or tissue
0.73
biological term
0.68
co-expressed gene
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 984.94   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 504   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 984.94   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (180)
CHD8
Tbio
Family:  Epigenetic
Novelty:  0.01177693
p_int:  0.999982355
p_ni:  0.000017645
Data Source:  BioPlex
TRIM33
Tchem
Family:  Epigenetic
Novelty:  0.00415877
p_int:  0.999916415
p_ni:  0.000083586
Data Source:  BioPlex
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.999791085
p_ni:  0.000208913
p_wrong:  1e-9
Data Source:  BioPlex
CCDC102A
Tdark
Novelty:  1.89784272
p_int:  0.999677018
p_ni:  0.000322982
Data Source:  BioPlex
ATF7IP
Tbio
Novelty:  0.04269323
p_int:  0.997650149
p_ni:  0.002263675
p_wrong:  0.000086176
Data Source:  BioPlex
MGA
Tbio
Family:  TF
Novelty:  0.08965274
p_int:  0.997485411
p_ni:  0.002514589
Data Source:  BioPlex
BTBD9
Tbio
Novelty:  0.02793632
p_int:  0.996979629
p_ni:  0.003020371
p_wrong:  1e-9
Data Source:  BioPlex
YEATS2
Tbio
Novelty:  0.17584498
p_int:  0.994804675
p_ni:  0.005195325
Data Source:  BioPlex
ZZZ3
Tdark
Family:  TF
Novelty:  0.23862921
p_int:  0.991752054
p_ni:  0.008247938
p_wrong:  9e-9
Data Source:  BioPlex
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.984654776
p_ni:  0.015345224
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
2
2
64.2
waist-hip ratio
1
2
2
63.9
BMI-adjusted waist-hip ratio
1
2
2
61.8
mean platelet volume
1
1
1
49.5
red blood cell distribution width
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
2
64.2
waist-hip ratio
2
63.9
BMI-adjusted waist-hip ratio
2
61.8
mean platelet volume
1
49.5
red blood cell distribution width
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1916503
69253
Rat
RGD:70914
161476
Dog
heat shock protein family B (small) member 2
VGNC:53415
611362
Cow
heat shock protein family B (small) member 2
508671
Xenopus
heat shock protein family B (small) member 2
XB-GENE-940436
100497635
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
heat shock protein family B (small) member 2
Cow
heat shock protein family B (small) member 2
Xenopus
heat shock protein family B (small) member 2
Publication Statistics
PubMed Score 984.94
PubMed score by year
PubTator Score 20.31
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title