HSPA5
Endoplasmic reticulum chaperone BiP
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
chemical | 1 | ||
disease perturbation | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
molecular function | 1 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ATF6 (ATF6-alpha) activates chaperone genes | ||||
Reactome | ATF6 (ATF6-alpha) activates chaperones | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ||||
Reactome | Cellular response to heat stress | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ATF6 (ATF6-alpha) activates chaperone genes | ||||
ATF6 (ATF6-alpha) activates chaperones | ||||
Adaptive Immune System | ||||
Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ||||
Cellular response to heat stress | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | AgBase | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 2 | 2 | 67.8 | |||||
smoking cessation | 2 | 1 | 2 | 65.9 | |||||
worry measurement | 1 | 1 | 0 | 6.1 | 35 | ||||
cigarettes per day measurement | 1 | 1 | 1 | 24.5 | |||||
neuroticism measurement | 1 | 1 | 1 | 11.1 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 67.8 | |||||
smoking cessation | 2 | 65.9 | |||||
worry measurement | 0 | 6.1 | 35 | ||||
cigarettes per day measurement | 1 | 24.5 | |||||
neuroticism measurement | 1 | 11.1 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | heat shock protein family A (Hsp70) member 5 | VGNC:4760 | 464733 | |||||
Macaque | heat shock protein family A (Hsp70) member 5 | 703193 | ||||||
Mouse | MGI:95835 | 14828 | ||||||
Rat | RGD:2843 | 25617 | ||||||
Dog | heat shock protein family A (Hsp70) member 5 | 480726 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | heat shock protein family A (Hsp70) member 5 | |||||
Macaque | heat shock protein family A (Hsp70) member 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | heat shock protein family A (Hsp70) member 5 | |||||
PMID | Year | Title |
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