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Tbio
HSPA4
Heat shock 70 kDa protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304858
  • ENSP00000302961
  • ENSG00000170606

Symbol
  • APG2
  • RY
  • APG-2
  • HSPH2
  • hsp70
  • hsp70RY
  • HEL-S-5a
  • HS24/P52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
biological term
0.99
disease perturbation
0.98
transcription factor binding site profile
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12238.41   (req: < 5)
Gene RIFs: 269   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12238.41   (req: >= 5)
Gene RIFs: 269   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (769)
TUSC2
Tbio
Novelty:  0.05958876
p_int:  0.998480738
p_ni:  0.001519262
Data Source:  BioPlex
TCAP
Tbio
Novelty:  0.00623581
p_int:  0.883880053
p_ni:  0.116119947
Score:  0.197
Data Source:  BioPlex,STRINGDB
TRMT12
Tbio
Family:  Enzyme
Novelty:  0.12417204
p_int:  0.862272289
p_ni:  0.137727711
Score:  0.348
Data Source:  BioPlex,STRINGDB
SLC27A3
Tbio
Family:  Transporter
Novelty:  0.1037612
p_int:  0.859930918
p_ni:  0.140069082
Score:  0.239
Data Source:  BioPlex,STRINGDB
SNX20
Tbio
Novelty:  0.28934317
p_int:  0.84434012
p_ni:  0.15565988
Score:  0.187
Data Source:  BioPlex,STRINGDB
METTL21A
Tbio
Family:  Enzyme
Novelty:  0.31897774
p_int:  0.843869876
p_ni:  0.156130124
Score:  0.699
Data Source:  BioPlex,STRINGDB
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
p_int:  0.80852217
p_ni:  0.19147783
Score:  0.242
Data Source:  BioPlex,STRINGDB
TTC9B
Tdark
Novelty:  0.25942345
p_int:  0.755165318
p_ni:  0.244834682
Score:  0.332
Data Source:  BioPlex,STRINGDB
DNAJB1
Tbio
Novelty:  0.00139956
Score:  0.999
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (63)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
6
5
6
92.1
BMI-adjusted waist-hip ratio
7
6
11
92
heel bone mineral density
2
2
2
87.7
diastolic blood pressure
2
2
2
79
waist-hip ratio
2
2
2
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
6
92.1
BMI-adjusted waist-hip ratio
11
92
heel bone mineral density
2
87.7
diastolic blood pressure
2
79
waist-hip ratio
2
77.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 4
VGNC:6935
462060
Macaque
heat shock protein family A (Hsp70) member 4
709585
Mouse
MGI:1342292
15525
Rat
RGD:628878
266759
Dog
heat shock protein family A (Hsp70) member 4
VGNC:51724
474680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 4
Macaque
heat shock protein family A (Hsp70) member 4
Mouse
Rat
Dog
heat shock protein family A (Hsp70) member 4
Publication Statistics
PubMed Score 12238.41
PubMed score by year
PubTator Score 3912.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title