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Tbio
HSPA1L
Heat shock 70 kDa protein 1-like

Protein Summary
Description
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and rel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375654
  • ENSP00000364805
  • ENSG00000204390
  • ENST00000383390
  • ENSP00000372881
  • ENSG00000206383
  • ENST00000417601
  • ENSP00000396486
  • ENSG00000234258
  • ENST00000456772
  • ENSP00000408347
  • ENSG00000236251

Symbol
  • HSP70T
  • hum70t
  • HSP70-1L
  • HSP70-HOM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
protein complex
1
disease
0.85
molecular function
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.01   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.01   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.97767808
p_ni:  0.02232192
Data Source:  BioPlex
FUK
Tbio
Family:  Kinase
Novelty:  0.05169095
p_int:  0.944487666
p_ni:  0.055512334
Data Source:  BioPlex
SOHLH1
Tbio
Family:  TF
Novelty:  0.04218087
p_int:  0.898805612
p_ni:  0.101194388
Data Source:  BioPlex
ELP4
Tbio
Novelty:  0.03734233
p_int:  0.897656492
p_ni:  0.102343508
Data Source:  BioPlex
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.876049415
p_ni:  0.123950585
Data Source:  BioPlex
ANKRD13A
Tbio
Novelty:  0.61940334
p_int:  0.858382304
p_ni:  0.141617696
Data Source:  BioPlex
CCDC142
Tdark
Novelty:  1.2
p_int:  0.845021932
p_ni:  0.154978068
Data Source:  BioPlex
ARMC5
Tbio
Novelty:  0.02895521
p_int:  0.831973371
p_ni:  0.168026629
Data Source:  BioPlex
CERCAM
Tdark
Family:  Enzyme
Novelty:  0.33392502
p_int:  0.806424991
p_ni:  0.193575009
Data Source:  BioPlex
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
p_int:  0.796589328
p_ni:  0.203410672
Data Source:  BioPlex
Pathways (22)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (268)
Items per page:
1 – 5 of 268
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
15
19
97.9
BMI-adjusted waist-hip ratio
5
15
19
97.9
BMI-adjusted waist-hip ratio
5
15
19
97.9
BMI-adjusted waist-hip ratio
5
15
19
97.9
3
3
0
2.3
96
Items per page:
1 – 5 of 268
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
19
97.9
BMI-adjusted waist-hip ratio
19
97.9
BMI-adjusted waist-hip ratio
19
97.9
BMI-adjusted waist-hip ratio
19
97.9
0
2.3
96
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
heat shock 70 kDa protein 1-like
716633
Mouse
MGI:96231
15482
Rat
RGD:1595925
24963
Cow
heat shock 70kDa protein 1-like
540190
Species
Name
OMA
EggNOG
Inparanoid
Macaque
heat shock 70 kDa protein 1-like
Mouse
Rat
Cow
heat shock 70kDa protein 1-like
Publication Statistics
PubMed Score 54.01
PubMed score by year
PubTator Score 43.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title