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Tbio
HSPA12A
Heat shock 70 kDa protein 12A

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369209
  • ENSP00000358211
  • ENSG00000165868

Symbol
  • KIAA0417
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
histone modification site profile
0.75
molecular function
0.73
microRNA
0.63
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.24   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.24   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
TMEM51
Tdark
Novelty:  0.54147214
p_int:  0.999774355
p_ni:  0.000225644
p_wrong:  1e-9
Data Source:  BioPlex
PODXL
Tbio
Novelty:  0.00306913
p_int:  0.999577225
p_ni:  0.000422775
Score:  0.162
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999140171
p_ni:  0.000859828
p_wrong:  1e-9
Data Source:  BioPlex
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.997183281
p_ni:  0.002816719
Score:  0.182
Data Source:  BioPlex,STRINGDB
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.989182467
p_ni:  0.01081753
p_wrong:  3e-9
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.987769535
p_ni:  0.012230465
Score:  0.186
Data Source:  BioPlex,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.9651282
p_ni:  0.034871699
p_wrong:  1.01e-7
Data Source:  BioPlex
TNF
Tclin
Novelty:  0.00001457
p_int:  0.956488665
p_ni:  0.043511328
p_wrong:  7e-9
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.902147193
p_ni:  0.097852803
p_wrong:  4e-9
Data Source:  BioPlex
CCL22
Tbio
Novelty:  0.00245992
p_int:  0.898999804
p_ni:  0.101000009
p_wrong:  1.88e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
2
2
0
18.4
95.3
low density lipoprotein cholesterol measurement
4
2
4
88.9
phosphatidylcholine measurement
3
5
10
87.9
cup-to-disc ratio measurement
3
2
3
84.8
brain measurement
1
1
0
22.6
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
18.4
95.3
low density lipoprotein cholesterol measurement
4
88.9
phosphatidylcholine measurement
10
87.9
cup-to-disc ratio measurement
3
84.8
brain measurement
0
22.6
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
heat shock protein family A (Hsp70) member 12A
707202
Mouse
MGI:1920692
73442
Rat
RGD:1305531
307997
Dog
heat shock protein family A (Hsp70) member 12A
VGNC:52995
486904
Cow
heat shock protein family A (Hsp70) member 12A
540050
Species
Name
OMA
EggNOG
Inparanoid
Macaque
heat shock protein family A (Hsp70) member 12A
Mouse
Rat
Dog
heat shock protein family A (Hsp70) member 12A
Cow
heat shock protein family A (Hsp70) member 12A
Publication Statistics
PubMed Score 14.24
PubMed score by year
PubTator Score 2.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title