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Tchem
HSP90B1
Endoplasmin

Protein Summary
Description
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299767
  • ENSP00000299767
  • ENSG00000166598

Symbol
  • GRP94
  • TRA1
  • ECGP
  • GP96
  • TRA1
  • GRP94
  • HEL35
  • HEL-S-125m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.98
molecular function
0.97
virus perturbation
0.94
biological process
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 799.41   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 1239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 799.41   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 1239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
2
0
3.2
88.3
intraocular pressure measurement
1
2
2
69.1
heel bone mineral density
2
2
2
65.7
corneal topography
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3.2
88.3
intraocular pressure measurement
2
69.1
heel bone mineral density
2
65.7
corneal topography
1
42.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein 90 beta family member 1
VGNC:5423
452187
Macaque
heat shock protein 90 beta family member 1
699568
Mouse
MGI:98817
22027
Rat
RGD:1310482
362862
Dog
heat shock protein 90 beta family member 1
VGNC:54212
404019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein 90 beta family member 1
Macaque
heat shock protein 90 beta family member 1
Mouse
Rat
Dog
heat shock protein 90 beta family member 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14625-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
ATF6 (ATF6-alpha) activates chaperone genes (R-HSA-381183)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF6 (ATF6-alpha) activates chaperone genes
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperones
Binding and Uptake of Ligands by Scavenger Receptors
Cytokine Signaling in Immune system
Immune System
Gene Ontology Terms (40)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (420)
1 – 10 of 420
OS9
Tbio
Novelty:  0.01490339
p_int:  0.96153235
p_ni:  0.03846765
Score:  0.969
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.757309725
p_ni:  0.242690275
Score:  0.239
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.999
Data Source:  STRINGDB
CALR
Tbio
Novelty:  0.0004479
Score:  0.999
Data Source:  STRINGDB
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
Score:  0.998
Data Source:  STRINGDB
PDIA6
Tchem
Family:  Enzyme
Novelty:  0.01692178
Score:  0.997
Data Source:  STRINGDB
DNAJC3
Tbio
Novelty:  0.02129782
Score:  0.995
Data Source:  STRINGDB
HYOU1
Tbio
Novelty:  0.00833649
Score:  0.995
Data Source:  STRINGDB
PRKCSH
Tbio
Family:  Enzyme
Novelty:  0.00787916
Score:  0.994
Data Source:  STRINGDB
PDIA4
Tbio
Family:  Enzyme
Novelty:  0.01412168
Score:  0.991
Data Source:  STRINGDB
Publication Statistics
PubMed Score  799.41

PubMed score by year
PubTator Score  415.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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