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Tbio
HSF4
Heat shock factor protein 4

Protein Summary
Description
DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000521374
  • ENSP00000430947
  • ENSG00000102878
  • ENST00000584272
  • ENSP00000463706

Symbol
  • CTM
  • CTRCT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.84
co-expressed gene
0.69
tissue sample
0.69
cell type or tissue
0.63
PubMedID
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.27   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.27   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
LIM2
Tbio
Novelty:  0.01252353
Score:  0.844
Data Source:  STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
Score:  0.84
Data Source:  STRINGDB
CRYBB2
Tbio
Novelty:  0.00721869
Score:  0.81
Data Source:  STRINGDB
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.795
Data Source:  STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.795
Data Source:  STRINGDB
CRYBB1
Tbio
Novelty:  0.01083645
Score:  0.778
Data Source:  STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
Score:  0.762
Data Source:  STRINGDB
VSIG2
Tbio
Novelty:  0.32398032
Score:  0.755
Data Source:  STRINGDB
GJA3
Tbio
Novelty:  0.00638283
Score:  0.73
Data Source:  STRINGDB
CHMP4B
Tbio
Novelty:  0.01391352
Score:  0.728
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
4
4
87.9
mean reticulocyte volume
2
4
5
85.9
high density lipoprotein cholesterol measurement
2
3
3
83.8
heel bone mineral density
1
1
1
80.5
balding measurement
1
1
1
42.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
87.9
mean reticulocyte volume
5
85.9
high density lipoprotein cholesterol measurement
3
83.8
heel bone mineral density
1
80.5
balding measurement
1
42.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
heat shock transcription factor 4
698412
Mouse
MGI:1347058
26386
Rat
RGD:1310808
291960
Dog
heat shock transcription factor 4
489766
Horse
heat shock transcription factor 4
VGNC:18895
100052978
Species
Name
OMA
EggNOG
Inparanoid
Macaque
heat shock transcription factor 4
Mouse
Rat
Dog
heat shock transcription factor 4
Horse
heat shock transcription factor 4
Publication Statistics
PubMed Score 87.27
PubMed score by year
PubTator Score 68.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title