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Tbio
HSF2
Heat shock factor protein 2

Protein Summary
Description
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368455
  • ENSP00000357440
  • ENSG00000025156
  • ENST00000452194
  • ENSP00000400380

Symbol
  • HSTF2
  • HSF 2
  • HSTF 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.73
transcription factor perturbation
0.68
transcription factor binding site profile
0.66
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.4   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 608   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.4   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 608   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0