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Tchem
HSD17B7
3-keto-steroid reductase

Protein Summary
Description
Responsible for the reduction of the keto group on the C-3 of sterols. HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254521
  • ENSP00000254521
  • ENSG00000132196

Symbol
  • SDR37C1
  • PRAP
  • SDR37C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
histone modification site profile
0.81
virus perturbation
0.72
transcription factor perturbation
0.68
tissue sample
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.15   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.15   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (115)
ACP5
Tbio
Family:  Enzyme
Novelty:  0.00034703
p_int:  0.996037303
p_ni:  0.003961562
p_wrong:  0.000001136
Score:  0.54
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.99517847
p_ni:  0.004642412
p_wrong:  0.000179118
Data Source:  BioPlex
POLB
Tchem
Family:  Enzyme
Novelty:  0.00145102
p_int:  0.995163097
p_ni:  0.004836599
p_wrong:  3.03e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.991347054
p_ni:  0.008626681
p_wrong:  0.000026265
Data Source:  BioPlex
ORAI1
Tchem
Family:  IC
Novelty:  0.00179685
p_int:  0.990462556
p_ni:  0.00940399
p_wrong:  0.000133453
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.99007358
p_ni:  0.009783963
p_wrong:  0.000142458
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.986382549
p_ni:  0.013497157
p_wrong:  0.000120293
Data Source:  BioPlex
SLC1A5
Tchem
Family:  Transporter
Novelty:  0.00201741
p_int:  0.985857961
p_ni:  0.014142039
Score:  0.165
Data Source:  BioPlex,STRINGDB
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.970330547
p_ni:  0.029669311
p_wrong:  1.42e-7
Data Source:  BioPlex
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.929812276
p_ni:  0.069585971
p_wrong:  0.000601753
Data Source:  BioPlex
Pathways (24)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
71.6
Dupuytren Contracture
1
1
0
1.2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
71.6
Dupuytren Contracture
0
1.2
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 7
VGNC:11452
747814
Macaque
hydroxysteroid 17-beta dehydrogenase 7
720399
Mouse
MGI:1330808
15490
Rat
RGD:2837
29540
Dog
hydroxysteroid 17-beta dehydrogenase 7
VGNC:41809
609364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 7
Macaque
hydroxysteroid 17-beta dehydrogenase 7
Mouse
Rat
Dog
hydroxysteroid 17-beta dehydrogenase 7
Publication Statistics
PubMed Score 25.15
PubMed score by year
PubTator Score 273.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title