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Tbio
HSD17B6
17-beta-hydroxysteroid dehydrogenase type 6

Protein Summary
Description
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322165
  • ENSP00000318631
  • ENSG00000025423
  • ENST00000554150
  • ENSP00000452273
  • ENST00000554643
  • ENSP00000451406
  • ENST00000555159
  • ENSP00000450698
  • ENST00000555805
  • ENSP00000451753

Symbol
  • RODH
  • SDR9C6
  • HSE
  • RODH
  • SDR9C6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.67
gene perturbation
0.62
protein domain
0.58
cellular component
0.55
small molecule perturbation
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.84   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.84   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.999998316
p_ni:  0.000001684
Score:  0.372
Data Source:  BioPlex,STRINGDB
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.999991122
p_ni:  0.000008878
Score:  0.161
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999959329
p_ni:  0.000040671
Data Source:  BioPlex
PRTFDC1
Tbio
Family:  Enzyme
Novelty:  0.13607881
p_int:  0.985019062
p_ni:  0.004077268
p_wrong:  0.01090367
Score:  0.187
Data Source:  BioPlex,STRINGDB
TATDN1
Tbio
Family:  Enzyme
Novelty:  0.12964405
p_int:  0.983706523
p_ni:  0.000838889
p_wrong:  0.015454588
Score:  0.519
Data Source:  BioPlex,STRINGDB
ATP2B1
Tbio
Family:  Transporter
Novelty:  0.00706808
p_int:  0.974843796
p_ni:  0.025156204
Score:  0.52
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.974636852
p_ni:  0.025362809
p_wrong:  3.39e-7
Data Source:  BioPlex
PPP1R14B
Tbio
Family:  Enzyme
Novelty:  0.04722141
p_int:  0.940547347
p_ni:  0.05384629
p_wrong:  0.005606363
Score:  0.359
Data Source:  BioPlex,STRINGDB
GNPNAT1
Tbio
Family:  Enzyme
Novelty:  0.01739665
p_int:  0.89637189
p_ni:  0.090899188
p_wrong:  0.012728921
Score:  0.188
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.877124276
p_ni:  0.122875724
Score:  0.204
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (12)
Explore Nearest Tclin Targets
1 – 5 of 9
DGAT1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
SRD5A2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
CYP19A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (26)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
The canonical retinoid cycle in rods (twilight vision)
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
The canonical retinoid cycle in rods (twilight vision)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
1
3
79.9
mean corpuscular hemoglobin concentration
1
1
1
78.9
platelet count
1
1
1
74.5
mean corpuscular volume
1
1
1
73.5
reticulocyte count
3
2
3
73.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
79.9
mean corpuscular hemoglobin concentration
1
78.9
platelet count
1
74.5
mean corpuscular volume
1
73.5
reticulocyte count
3
73.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1351670
27400
Rat
RGD:708343
286964
Dog
hydroxysteroid 17-beta dehydrogenase 6
VGNC:41808
481118
Cow
hydroxysteroid (17-beta) dehydrogenase 6
533086
Pig
17-beta-hydroxysteroid dehydrogenase type 6
100620470
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
hydroxysteroid 17-beta dehydrogenase 6
Cow
hydroxysteroid (17-beta) dehydrogenase 6
Pig
17-beta-hydroxysteroid dehydrogenase type 6
Publication Statistics
PubMed Score 67.84
PubMed score by year
PubTator Score 394.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text