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Tchem
HSD17B3
Testosterone 17-beta-dehydrogenase 3

Protein Summary
Description
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375262
  • ENSP00000364411
  • ENSG00000130948
  • ENST00000375263
  • ENSP00000364412

Symbol
  • EDH17B3
  • SDR12C2
  • EDH17B3
  • SDR12C2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
protein domain
0.58
co-expressed gene
0.57
disease
0.52
cellular component
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.26   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.26   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 152
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2