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Tchem
HSD17B2
Estradiol 17-beta-dehydrogenase 2

Protein Summary
Description
Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000199936
  • ENSP00000199936
  • ENSG00000086696

Symbol
  • EDH17B2
  • SDR9C2
  • HSD17
  • SDR9C2
  • EDH17B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
phenotype
0.8
virus perturbation
0.79
PubMedID
0.74
disease
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.11   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.11   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 414
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1