Tchem HSD17B2 Estradiol 17-beta-dehydrogenase 2

Protein Summary

Description

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.

Uniprot Accession IDs

• P37059
• B2R7T4

Gene Name

• HSD17B2

Ensembl ID

• ENST00000199936
• ENSP00000199936
• ENSG00000086696

Symbol

• EDH17B2
• SDR9C2
• HSD17
• SDR9C2
• EDH17B2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
phenotype	0.8
virus perturbation	0.79
PubMedID	0.74
disease	0.65

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Estradiol 17-beta-dehydrogenase 2

Protein / Oxidoreductase / Dehydrogenase / Estradiol 17-beta-dehydrogenase 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Estradiol 17-beta-dehydrogenase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.11   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 283   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.11   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 414

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1