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Tbio
HSD17B12
Very-long-chain 3-oxoacyl-CoA reductase

Protein Summary
Description
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278353
  • ENSP00000278353
  • ENSG00000149084
  • ENST00000395700
  • ENSP00000379052

Symbol
  • SDR12C1
  • KAR
  • SDR12C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
interacting protein
0.85
transcription factor perturbation
0.8
virus perturbation
0.76
transcription factor binding site profile
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.88   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.88   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
ELOVL1
Tbio
Novelty:  0.03178348
Score:  0.973
Data Source:  STRINGDB
HACD1
Tbio
Family:  Enzyme
Novelty:  0.02323512
Score:  0.971
Data Source:  STRINGDB
HACD2
Tbio
Family:  Enzyme
Novelty:  0.16943742
Score:  0.969
Data Source:  STRINGDB
ELOVL5
Tbio
Novelty:  0.00536344
Score:  0.966
Data Source:  STRINGDB
TECR
Tbio
Family:  Enzyme
Novelty:  0.00114749
Score:  0.965
Data Source:  STRINGDB
ELOVL4
Tbio
Novelty:  0.00737822
Score:  0.963
Data Source:  STRINGDB
ELOVL6
Tchem
Novelty:  0.00817818
Score:  0.96
Data Source:  STRINGDB
HACD3
Tbio
Family:  Enzyme
Novelty:  0.07336359
Score:  0.957
Data Source:  STRINGDB
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
Score:  0.957
Data Source:  STRINGDB
HACD4
Tbio
Family:  Enzyme
Novelty:  0.20315286
Score:  0.956
Data Source:  STRINGDB
Pathways (16)
Androgen biosynthesis (R-HSA-193048)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
6
11
95.1
body height
1
2
2
78
chronotype measurement
3
3
2
1
72.6
fibrinogen measurement
3
2
3
69.6
vital capacity
2
2
1
16.7
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
11
95.1
body height
2
78
chronotype measurement
2
1
72.6
fibrinogen measurement
3
69.6
vital capacity
1
16.7
63.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 12
VGNC:11820
741010
Macaque
hydroxysteroid 17-beta dehydrogenase 12
106993263
Mouse
MGI:1926967
56348
Rat
RGD:708367
84013
Dog
hydroxysteroid 17-beta dehydrogenase 12
VGNC:41802
475939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 12
Macaque
hydroxysteroid 17-beta dehydrogenase 12
Mouse
Rat
Dog
hydroxysteroid 17-beta dehydrogenase 12
Publication Statistics
PubMed Score 47.88
PubMed score by year
PubTator Score 18.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title