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Tchem
HSD17B1
Estradiol 17-beta-dehydrogenase 1

Protein Summary
Description
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585807
  • ENSP00000466799
  • ENSG00000108786

Symbol
  • E17KSR
  • EDH17B1
  • EDH17B2
  • EDHB17
  • SDR28C1
  • E2DH
  • HSD17
  • EDHB17
  • EDH17B2
  • SDR28C1
  • 17-beta-HSD
  • 20-alpha-HSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.85
protein domain
0.73
biological term
0.69
gene perturbation
0.69
PubMedID
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.34   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.34   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 399
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1